2013 Researcher Dr. Sabine Mai

Characterization of ependymomas into favourable and non-favourable groups based on their 3D nuclear telomere profiles.

brain tumour researcher dr sabine mai
Dr. Sabine Mai
Manitoba Institute of Cell Biology, Winnipeg, MB
Award: $25,000


 

 

Project Summary:

The proposed study focuses on ependymoma, a childhood brain tumour. At diagnosis, it is not possible to know which child will respond to treatment and which child will recur, i.e. if prognosis is favourable or non-favourable. We have developed quantitative tools that may allow for the distinction of good and poor responders at diagnosis.

These tools involve three-dimensional (3D) imaging of telomeres. Telomeres are the ends of chromosomes; they protect the chromosomes from damage and prevent recombination and fusion with other chromosomes (Mai, 2010). Telomere dysfunction therefore is associated with genomic instability and found in many cancers (Mai and Garini, 2006; Mai, 2010).

The data obtained in this study are quantitatively measured, and the output is expected to be a 3D nuclear telomeric profile of each child’s tumour, indicative of favourable or non-favourable disease and will, in the near future, enable for the first time a choice for specific treatments for each child’s ependymoma.

<back to 2013 Grant Awardees

Share This

Featured Story

Meagan's Story: The best Christmas gift...

The best Christmas gift I could get would be to get this lump of coal out of my head. However, I do have good days. And recently, a lot more good days than bad. This is how I know that I will overcome this. This is how I know that my “new normal” won’t be so bad. One day at a time, and counting everything I am grateful for along the way.

Learn more

Spotlight

Steve and Iris: Story of Hope

Stephen was diagnosed with an anaplastic oligodendroglioma (grade III) in November of 2015 at the age of 53 years old, and shares his...

Learn more

Bloom Family's Story: Finding hope amid the grief

When you look back at Brain Tumour Foundation of Canada’s history, it’s clear that at the heart of the organization are the patients,...

Learn more

Upcoming Events

  • 24/Jan/2017: Groupe de soutien virtuel: Un groupe de soutien virtuel pour personnes touchées par une tumeur... Learn more >
  • 25/Jan/2017: Toronto Support Group: Wellspring Westerkirk House at Sunnybrook, Toronto, ON... Learn more >
  • 26/Jan/2017: Virtual Support Group East: Virtual Support Group for Eastern Canada... Learn more >
  • 26/Jan/2017: Sarnia Support Group: Meets at St. Giles Presbyterian Church,770 Lakeshore Road Sarnia, ON... Learn more >
View All Events >
Thank you to the donors whose contributions make this website and all programs, services and research possible.

Copyright © 2017 Brain Tumour Foundation of Canada. Charitable Registration #BN118816339RR0001
Imagine Canada Ethical Code