2011 Researcher Dr. Bertrand

Name and Title: Dr. Jean-Claude Bertrand J,  Associate Professor of Medicine/Medicinal Chemistry
Location: Royal Victoria Hospital/McGill University Health Centre, Montreal, Quebec
Grant Amount: $25,000
Title of Project: Brain penetrability and in vivo potency of novel multi-targeted combi-drugs

Research Summary: 

Glioblastoma multiforme (GBM) is the most aggressive form of primary brain tumours. Forty to fifty percent of primary central nervous system tumours are gliomas and, of these, 50% are GBMs. Grade IV gliomas grow rapidly, invading the brain causing death within 3 months if no appropriate treatment is administered. In order to induce significant cell killing in these aggressive tumours, drugs capable of blocking targets are required. Our laboratory has now designed and synthesized such type of drugs directed at proteins termed EGFR, EGFRvIII, Src that drive tumour progression and reduce tumour sensitivity to chemotherapeutic drugs.

In order to block the progression of these aggressive tumours, novel type of multitargeted molecules are urgently needed. Our laboratory has now designed and synthesize such type of molecules termed “combi-molecules”. The purpose of this proposal is to study their ability to penetrate into the brain and to strike the tumours at multiple targets (e.g. EGFR, EGFRvIII, Src) that shield them against the effects of chemotherapeutic drugs.

Return to the 2011 Research Grant List here.
 

Share This

Featured Story

Courtney’s Story of Stability

Stability. It’s a strange concept when you have what it known to be a progressive, life long illness. You hear the words, “Your tumour growth is stable” and for a moment you think someone is playing the world’s worst prank on you.

Learn more

Spotlight

Stephen's Story: "I have faith that we will meet again"

Stephen and I chatted on what should have been his 32nd Wedding Anniversary. Stephen and Susan were married for 30 years and were best...

Learn more

Tommy's Story: Fellowship recipient

Dr. Tommy Alain, the very first research Fellow funded by Brain Tumour Foundation of Canada through the William Donald Nash Brain...

Learn more

Upcoming Events

  • 23/Jan/2018: Groupe de soutien virtuel: Un groupe de soutien virtuel pour personnes touchées par une tumeur... Learn more >
  • 25/Jan/2018: Virtual Support Group East: Virtual Support Group for Eastern Canada... Learn more >
  • 25/Jan/2018: Sarnia Support Group: Meets at St. Giles Presbyterian Church,770 Lakeshore Road Sarnia, ON... Learn more >
  • 29/Jan/2018: Greater Sudbury Support Group: Meets at The Parkside Centre, 140 Durham Street, Sudbury, Ontario... Learn more >
View All Events >
Thank you to the donors whose contributions make this website and all programs, services and research possible.

Copyright © 2018 Brain Tumour Foundation of Canada. Charitable Registration #BN118816339RR0001
35 Years