2011 Researcher Dr. Morin

Name and Title:

Dr. Pier Jr Morin, Assistant Professor of Biochemistry

Location: University of Moncton, Moncton, New Brunswick
Grant Amount: $20,050.00
Research Title:

Understanding the Impact of tribbles proteins on glioblastoma development

Research Summary: 

Malignant gliomas are the most common and deadly brain tumours. Nearly 2,600 cases of brain tumours were reported in Canada last year and the mean survival rate for a patient diagnosed with a glioblastoma multiforme, the most aggressive glioma, remained slightly over one year. Targeted therapies stemming from a better understanding of the molecular footprints characterizing these tumors have emerged as promising therapeutic approaches for the treatment of glioblastomas. The current proposal aims at characterizing one such footprint, a group of proteins showing increased levels in glioblastoma tumor samples, and at confirming then as bona fide Achilles heel underlying this type of tumor.

Differentially regulated protein kinases, key regulators of signal transduction, have garnered interest as druggable targets in glioblastomas. This project looks at two kinase targets that have been shown to be overexpressed in preliminary work; the tribbles proteins Trib1 and Trib2. While these proteins possess oncogenic properties in other cancer types, their precise role in glioblastomas is unclear. This proposal will look at the expression levels of these leads and undertake functional studies to assess their impact on glioblastoma progression thus setting the stage for the development of a tribbles-focused therapeutic approach in glioblastomas.

Research Outcome:

Improving our knowledge of the metabolic cascades associated with inherent and acquired temozolomide resistance in GBMs is, hence, of uttermost importance and was investigated as part of this research grant. Results collected within the current research program serve as a springboard to (1) develop a combinatorial therapeutic strategy directed towards these new targets and aimed at circumventing temozolomide resistance in GBMs and to (2) identify a signature of metabolites in temozolomide-resistant GBM patients that will pave the way for the development of an early detection test of patients not responding to temozolomide. In addition, it is important to mention that the financial help provided by Brain Tumour Foundation of Canada was instrumental in assisting a young investigator (Dr. Morin) in setting up a strong research environment in Eastern Canada and ensuring that this quickly translated to funding at the national level. This grant undoubtedly contributed to our objectives and the key results. Our understanding of the molecular footprint associated with GBMs has been greatly improved. Read more about this research and the outcomes in Dr. Morin's report.

Return to the 2011 Research Grant list here.

Share This

Featured Story

Courtney’s Story of Stability

Stability. It’s a strange concept when you have what it known to be a progressive, life long illness. You hear the words, “Your tumour growth is stable” and for a moment you think someone is playing the world’s worst prank on you.

Learn more

Spotlight

Stephen's Story: "I have faith that we will meet again"

Stephen and I chatted on what should have been his 32nd Wedding Anniversary. Stephen and Susan were married for 30 years and were best...

Learn more

Tommy's Story: Fellowship recipient

Dr. Tommy Alain, the very first research Fellow funded by Brain Tumour Foundation of Canada through the William Donald Nash Brain...

Learn more

Upcoming Events

  • 16/Jan/2018: North Bay Support Group: Meets at St. Luke's Catholic Elementary School, 225 Milani Road, North Bay.... Learn more >
  • 16/Jan/2018: New Glasgow Support Group: Meets at East Haven Manor, 695 East River Road in New Glasgow, NS ... Learn more >
  • 17/Jan/2018: Windsor Support Group: Meets at the United Way, Unit A1, 300 Giles Blvd. East... Learn more >
  • 17/Jan/2018: Calgary Support Group: Meets at Wellspring Calgary, 1404 Home Road NW, Calgary, Alberta, T3B 1G7... Learn more >
View All Events >
Thank you to the donors whose contributions make this website and all programs, services and research possible.

Copyright © 2018 Brain Tumour Foundation of Canada. Charitable Registration #BN118816339RR0001
35 Years