2011 Researcher Dr. Alan Nichol

Name and Title: Dr. Alan Nichol, Radiation Oncologist
Location: BC Cancer Agency, Vancouver, BC
Grant Amount: $25,000
Title of Project: A Phase II study using 18F-FDOPA positron emission tomography for planning of neurosurgery and assessment of resection for high-grade gliomas

 Research Summary: 

Neurosurgeons use computed tomography (CT) and magnetic resonance imaging (MRI) to plan surgery for malignant brain tumours. These high-grade gliomas enhance when intravenous contrast is given for brain imaging. The aim of contemporary neurosurgery is to remove as much of the enhancing tumour as possible without causing disability for patients. However, outside the enhancing area, in parts of the brain that appear merely swollen on CT and MRI, there are also tumour cells.

The 18F-FDOPA positron emission tomography (PET) tracer is an amino-acid analogue that is taken up by tumour cells. It can be injected intravenously and imaged with a PET scanner to find additional tumour cells in the parts of the brain that appear swollen. In this study, neurosurgeons will be provided with both MRI and 18F-FDOPA PET imaging for surgical planning. The extent of surgical resection will be studied by repeating the MRI and 18F-FDOPA PET imaging within a few days of surgery. It is hoped that use of the 18F-FDOPA PET imaging will facilitate better tumour resections and lead to better survival for patients.
Phase II.

Return to the 2011 Research Grant List here.


Share This

Featured Story

Childhood Brain Tumour Signs & Symptoms

Earlier this year, you gave us your feedback in a survey on brain tumour signs and symptoms. One of the things we did with that survey was to compile a list of the most common signs & symptoms for children. Now, as part of Childhood Cancer Awareness Month, we are sharing compelling quotes from that survey and urging you to share them with this link to see the symptoms: www.braintumour.ca/symptoms. Thank you!

Learn more


Anthony's Story is Our Story

I would like to take the opportunity to share "our" story. It’s actually my best friend Anthony's story, but I use the term "our"...

Learn more

Kate's Mum's Story

"May 2006 is a month I will never forget. That was the moment that everything became before the cancer, and after the cancer. It was a...

Learn more

Upcoming Events

  • 21/Oct/2018: Scotiabank Waterfront Marathon 2018: Toronto, ON... Learn more >
  • 24/Oct/2018: Ottawa Support Group: Meets at the Maplesoft Centre at 1500 Alta Vista Drive, Ottawa, ON.... Learn more >
  • 25/Oct/2018: Virtual Support Group East: Virtual Support Group for Eastern Canada... Learn more >
  • 27/Oct/2018: National Conference - Montreal: Hôtel Ruby Foo's, Montreal, QC & diffusion en direct... Learn more >
View All Events >
Thank you to the donors whose contributions make this website and all programs, services and research possible.

Copyright © 2018 Brain Tumour Foundation of Canada. Charitable Registration #BN118816339RR0001