2011 Researcher Dr. Alan Nichol

Name and Title: Dr. Alan Nichol, Radiation Oncologist
Location: BC Cancer Agency, Vancouver, BC
Grant Amount: $25,000
Title of Project: A Phase II study using 18F-FDOPA positron emission tomography for planning of neurosurgery and assessment of resection for high-grade gliomas

 Research Summary: 

Neurosurgeons use computed tomography (CT) and magnetic resonance imaging (MRI) to plan surgery for malignant brain tumours. These high-grade gliomas enhance when intravenous contrast is given for brain imaging. The aim of contemporary neurosurgery is to remove as much of the enhancing tumour as possible without causing disability for patients. However, outside the enhancing area, in parts of the brain that appear merely swollen on CT and MRI, there are also tumour cells.

The 18F-FDOPA positron emission tomography (PET) tracer is an amino-acid analogue that is taken up by tumour cells. It can be injected intravenously and imaged with a PET scanner to find additional tumour cells in the parts of the brain that appear swollen. In this study, neurosurgeons will be provided with both MRI and 18F-FDOPA PET imaging for surgical planning. The extent of surgical resection will be studied by repeating the MRI and 18F-FDOPA PET imaging within a few days of surgery. It is hoped that use of the 18F-FDOPA PET imaging will facilitate better tumour resections and lead to better survival for patients.
Phase II.

Return to the 2011 Research Grant List here.


Share This

Featured Story

Grey Matters - Blogger Tuesdays

Have you seen our blog lately? Read about people who are making a difference in the brain tumour community from our staff and volunteers to our donors, funded researchers, and medical experts. You will find advice, news, information, and interesting stories about people affected by a brain tumour. Who doesn't love a good story? You won't want to miss the inside scoop Grey Matters has in store for you!

Learn more


Roy and the Gamma Knife – A Happy Tale

I had headaches, almost daily, for 10 years or more. It was a rare day if I did not have a headache. I used to joke that I should own...

Learn more

Courtney’s Story of Stability

Stability. It’s a strange concept when you have what it known to be a progressive, life long illness. You hear the words, “Your tumour...

Learn more

Upcoming Events

  • 25/Apr/2018: Toronto Support Group: Meets at Wellspring Westerkirk House at Sunnybrook, Toronto, ON... Learn more >
  • 25/Apr/2018: Ottawa Support Group: Meets at the Maplesoft Centre at 1500 Alta Vista Drive, Ottawa, ON.... Learn more >
  • 26/Apr/2018: Brain Fair: BMO Centre, 295 Rectory St, London, ON... Learn more >
  • 26/Apr/2018: Sarnia Support Group: Meets at St. Giles Presbyterian Church,770 Lakeshore Road Sarnia, ON... Learn more >
View All Events >
Thank you to the donors whose contributions make this website and all programs, services and research possible.

Copyright © 2018 Brain Tumour Foundation of Canada. Charitable Registration #BN118816339RR0001