2012 Researcher Dr. Fortin

Characterization of the chemoresistance profiles of malignant gliomas- A step towards individualized treatments

brain tumour researcher dr david fortin


Dr. David Fortin
Universite de Sherbrooke, Sherbrooke, Quebec
Award: $25,000

 

What does the title mean?

This research focuses on the cells responsible for blocking treatment to the brain, specifically multi-drug resistant glioblastoma multiforme


Project Summary:

Glioblastoma multiforme (GBM) is the most frequent primary brain tumour. The incurability of this disease can partially be explained a chemoresistance phenomenon.

ABC transporter proteins are pumps expressed by glial cancer cells and by endothelial cell at the blood-brain barrier and blood-tumour barrier (BTB). In non-pathological conditions they protect the brain from drugs by insuring their exclusion from the brain, by pumping drugs back in the blood. However, these pumps are often overexpressed in cancer cells and give rise to chemoresistance to multiple anti-cancer drugs.

Research efforts to find specific inhibitors of theses transporters are currently in progress. Four members of this family of proteins have been identified to be express in malignant gliomas: MDR1, MRP1, MRP3, BCRP. Since the response to treatment is highly heterogeneous in GBM patients the search for novel biomarkers is crucial. The detailed characterization of the expression profile of ABC transporters could predict GBM progression and to allow the administration of a personalized treatment.

The aim of our research project is to characterize in glial cancer cells and BTB endothelial cells, the expression profile of four ABC transporters responsible for the drug delivery impediment to the brain and for the multidrug resistance in GBM patients.
 

Share This

Featured Story

Courtney’s Story of Stability

Stability. It’s a strange concept when you have what it known to be a progressive, life long illness. You hear the words, “Your tumour growth is stable” and for a moment you think someone is playing the world’s worst prank on you.

Learn more

Spotlight

Stephen's Story: "I have faith that we will meet again"

Stephen and I chatted on what should have been his 32nd Wedding Anniversary. Stephen and Susan were married for 30 years and were best...

Learn more

Tommy's Story: Fellowship recipient

Dr. Tommy Alain, the very first research Fellow funded by Brain Tumour Foundation of Canada through the William Donald Nash Brain...

Learn more

Upcoming Events

  • 16/Jan/2018: North Bay Support Group: Meets at St. Luke's Catholic Elementary School, 225 Milani Road, North Bay.... Learn more >
  • 16/Jan/2018: New Glasgow Support Group: Meets at East Haven Manor, 695 East River Road in New Glasgow, NS ... Learn more >
  • 17/Jan/2018: Windsor Support Group: Meets at the United Way, Unit A1, 300 Giles Blvd. East... Learn more >
  • 17/Jan/2018: Calgary Support Group: Meets at Wellspring Calgary, 1404 Home Road NW, Calgary, Alberta, T3B 1G7... Learn more >
View All Events >
Thank you to the donors whose contributions make this website and all programs, services and research possible.

Copyright © 2018 Brain Tumour Foundation of Canada. Charitable Registration #BN118816339RR0001
35 Years