2012 Researcher Dr. Fortin

Characterization of the chemoresistance profiles of malignant gliomas- A step towards individualized treatments

brain tumour researcher dr david fortin

Dr. David Fortin
Universite de Sherbrooke, Sherbrooke, Quebec
Award: $25,000


What does the title mean?

This research focuses on the cells responsible for blocking treatment to the brain, specifically multi-drug resistant glioblastoma multiforme

Project Summary:

Glioblastoma multiforme (GBM) is the most frequent primary brain tumour. The incurability of this disease can partially be explained a chemoresistance phenomenon.

ABC transporter proteins are pumps expressed by glial cancer cells and by endothelial cell at the blood-brain barrier and blood-tumour barrier (BTB). In non-pathological conditions they protect the brain from drugs by insuring their exclusion from the brain, by pumping drugs back in the blood. However, these pumps are often overexpressed in cancer cells and give rise to chemoresistance to multiple anti-cancer drugs.

Research efforts to find specific inhibitors of theses transporters are currently in progress. Four members of this family of proteins have been identified to be express in malignant gliomas: MDR1, MRP1, MRP3, BCRP. Since the response to treatment is highly heterogeneous in GBM patients the search for novel biomarkers is crucial. The detailed characterization of the expression profile of ABC transporters could predict GBM progression and to allow the administration of a personalized treatment.

The aim of our research project is to characterize in glial cancer cells and BTB endothelial cells, the expression profile of four ABC transporters responsible for the drug delivery impediment to the brain and for the multidrug resistance in GBM patients.

Share This

Featured Story

Kate's Mum's Story

"May 2006 is a month I will never forget. That was the moment that everything became before the cancer, and after the cancer. It was a mark in time that would forever change my family"... Read more about Kate's Mum's story from her diagnosis of glioblastoma in 2006 and how Mum has beaten the odds to still be here today.

Learn more


Roy and the Gamma Knife – A Happy Tale

I had headaches, almost daily, for 10 years or more. It was a rare day if I did not have a headache. I used to joke that I should own...

Learn more

Courtney’s Story of Stability

Stability. It’s a strange concept when you have what it known to be a progressive, life long illness. You hear the words, “Your tumour...

Learn more

Upcoming Events

  • 24/Jul/2018: Groupe de soutien virtuel: Un groupe de soutien virtuel pour personnes touchées par une tumeur... Learn more >
  • 25/Jul/2018: Toronto Support Group: Meets at Wellspring Westerkirk House at Sunnybrook, Toronto, ON... Learn more >
  • 29/Jul/2018: 11th Annual Black Diamond Car Show Presented by Thumbs Up: Black Diamond, AB... Learn more >
  • 02/Aug/2018: Ajax Support Group: Meets at St. Paul's United Church, 65 King's Crescent, Ajax, ON... Learn more >
View All Events >
Thank you to the donors whose contributions make this website and all programs, services and research possible.

Copyright © 2018 Brain Tumour Foundation of Canada. Charitable Registration #BN118816339RR0001