2012 Researcher Paula Foster

In Vivo MRI Characterization of Changing Blood-Tumour Barrier Permeability in a Mouse Model of Brain Metastasis

brain tumour researcher paula foster


Paula Foster
Robarts Research Institute: London, Ontario
Award: $23,500.00

What does the title mean?

This research focuses on the cells responsible for blocking treatment to the brain, specifically multi-drug resistant glioblastoma multiforme


Project Summary:


The most common tumours in the central nervous system are metastases originating from lung and breast cancer. Brain metastasis occurs in 15-25% of metastatic breast cancer patients. A diagnosis of brain metastases is terrifying. Untreated, the median survival time is 2–3 months; aggressive treatment extends this only marginally, to 4–12 months.

The blood brain barrier (BBB) tightly controls the passage of substrates from the blood into the brain and this hinders delivery of chemotherapeutics to metastatic tumours in the brain. When tumours develop the local BBB, sometimes referred to as the blood-tumor-barrier (BTB), can become leaky (or permeable). However, not all tumours are permeable. Within one individual there can exist both permeable and non-permeable tumours. This makes treatment very complicated.

In this project we are using a mouse model of breast cancer metastasis to the brain and advanced MRI tools to detect and monitor the leakiness of brain tumours over time in the whole brain. We expect our research will produce important information about what influences tumour growth and permeability in the brain. It is critical to understand the conditions that cause altered and heterogeneous BBB permeability in order to advance the development of treatments for brain tumours.
 

Share This

Featured Story

Kate's Mum's Story

"May 2006 is a month I will never forget. That was the moment that everything became before the cancer, and after the cancer. It was a mark in time that would forever change my family"... Read more about Kate's Mum's story from her diagnosis of glioblastoma in 2006 and how Mum has beaten the odds to still be here today.

Learn more

Spotlight

Roy and the Gamma Knife – A Happy Tale

I had headaches, almost daily, for 10 years or more. It was a rare day if I did not have a headache. I used to joke that I should own...

Learn more

Courtney’s Story of Stability

Stability. It’s a strange concept when you have what it known to be a progressive, life long illness. You hear the words, “Your tumour...

Learn more

Upcoming Events

  • 24/Jul/2018: Groupe de soutien virtuel: Un groupe de soutien virtuel pour personnes touchées par une tumeur... Learn more >
  • 25/Jul/2018: Toronto Support Group: Meets at Wellspring Westerkirk House at Sunnybrook, Toronto, ON... Learn more >
  • 29/Jul/2018: 11th Annual Black Diamond Car Show Presented by Thumbs Up: Black Diamond, AB... Learn more >
  • 02/Aug/2018: Ajax Support Group: Meets at St. Paul's United Church, 65 King's Crescent, Ajax, ON... Learn more >
View All Events >
Thank you to the donors whose contributions make this website and all programs, services and research possible.

Copyright © 2018 Brain Tumour Foundation of Canada. Charitable Registration #BN118816339RR0001