2012 Researcher Spencer Gibson

Targeting Bci-2 family members for treatment under hypoxia in glioblastoma multiforme tumours

brain tumour researcher spencer gibson
Spencer Gibson
University of Manitoba: Winnipeg, Manitoba


What does the title mean?

The research will provide insight into how to achieve effective treatment strategies that will target cells lacking oxygen in glioblastoma multiforme tumours, an environment in which the tumours adapt and thrive.

Project Summary:

Patients with glioblastoma (GBM) have a very poor prognosis with limited treatment options. The tumors have adapted to a microenvironment with extensive hypoxia (low oxygen levels), and elevated growth factor signaling to survive.

GBM tumors have increased activation of growth factor receptor EGFR and its mutated receptor, EGFRvIII allowing them to survive hypoxia.

We will investigate the role of Bcl-2 family members Mcl-1 and BNIP3 that are controlled by growth factors and hypoxia to determine whether we could block hypoxic survival signals that allow GBM cells to escape low oxygen conditions.

This study will provide insight into how to achieve effective treatment strategies that will target hypoxic cells in GBM tumours.

Share This

Featured Story

Courtney’s Story of Stability

Stability. It’s a strange concept when you have what it known to be a progressive, life long illness. You hear the words, “Your tumour growth is stable” and for a moment you think someone is playing the world’s worst prank on you.

Learn more


Stephen's Story: "I have faith that we will meet again"

Stephen and I chatted on what should have been his 32nd Wedding Anniversary. Stephen and Susan were married for 30 years and were best...

Learn more

Tommy's Story: Fellowship recipient

Dr. Tommy Alain, the very first research Fellow funded by Brain Tumour Foundation of Canada through the William Donald Nash Brain...

Learn more

Upcoming Events

  • 23/Jan/2018: Groupe de soutien virtuel: Un groupe de soutien virtuel pour personnes touchées par une tumeur... Learn more >
  • 25/Jan/2018: Virtual Support Group East: Virtual Support Group for Eastern Canada... Learn more >
  • 25/Jan/2018: Sarnia Support Group: Meets at St. Giles Presbyterian Church,770 Lakeshore Road Sarnia, ON... Learn more >
  • 29/Jan/2018: Greater Sudbury Support Group: Meets at The Parkside Centre, 140 Durham Street, Sudbury, Ontario... Learn more >
View All Events >
Thank you to the donors whose contributions make this website and all programs, services and research possible.

Copyright © 2018 Brain Tumour Foundation of Canada. Charitable Registration #BN118816339RR0001
35 Years