2012 Researcher Karen Goddard

Feasibility Study: Cerebrovascular disease and Late Effects in Survivors of Craniopharyngioma

Karen Goddard
BC Cancer Research Agency: Vancouver, British Columbia

What does the title mean?

The research will provide a model for screening and intervention of cerebrovascular disease in brain tumour survivors, a frequent long-term complication associated with the treatment of non-malignant craniopharyngiomas. [no photo]

Project Summary:

Survivors of both pediatric and young adult craniopharyngiomas are at risk for significant late effects. Although these tumors are benign, they generally require both surgery and high dose radiation therapy (RT) for long term control. Documented late health problems include hypopituitarism, cognitive disabilities, visual deficits and hypothalamic-obesity.

More recently, cerebrovascular disease (CVD) has also been found to be a frequent long-term complication, and this has not yet been studied in any significant number of patients. We do not know the frequency or types of CVD, the difference in onset and type between survivors of childhood versus young adult tumors, the amenability of these malformations to interventional therapy, the clinical correlation with TIAs and stroke-like symptoms, and the frequency of conditions such as obesity and hypertension which may increase the risk of CVD in survivors. We propose a comprehensive study to answer these questions involving clinical assessment and MR angiography.

We are conducting a feasibility study on an initial 20 survivors prior to a study involving the entire cohort. This research will provide a model for screening and intervention of CVD in brain tumour survivors. Our goal is to reduce late morbidity and mortality in this population.

Share This

Featured Story

Kate's Mum's Story

"May 2006 is a month I will never forget. That was the moment that everything became before the cancer, and after the cancer. It was a mark in time that would forever change my family"... Read more about Kate's Mum's story from her diagnosis of glioblastoma in 2006 and how Mum has beaten the odds to still be here today.

Learn more


Roy and the Gamma Knife – A Happy Tale

I had headaches, almost daily, for 10 years or more. It was a rare day if I did not have a headache. I used to joke that I should own...

Learn more

Courtney’s Story of Stability

Stability. It’s a strange concept when you have what it known to be a progressive, life long illness. You hear the words, “Your tumour...

Learn more

Upcoming Events

  • 24/Jul/2018: Groupe de soutien virtuel: Un groupe de soutien virtuel pour personnes touchées par une tumeur... Learn more >
  • 25/Jul/2018: Toronto Support Group: Meets at Wellspring Westerkirk House at Sunnybrook, Toronto, ON... Learn more >
  • 29/Jul/2018: 11th Annual Black Diamond Car Show Presented by Thumbs Up: Black Diamond, AB... Learn more >
  • 02/Aug/2018: Ajax Support Group: Meets at St. Paul's United Church, 65 King's Crescent, Ajax, ON... Learn more >
View All Events >
Thank you to the donors whose contributions make this website and all programs, services and research possible.

Copyright © 2018 Brain Tumour Foundation of Canada. Charitable Registration #BN118816339RR0001