Nash Fellowship Final Report

Research into two promising brain tumour therapies began in Montreal in the summer of 2010 as a result of the inaugural awarding of the William Donald Nash Brain Tumour Research Fellowship. Dr. Tommy Alain of McGill University was awarded the two-year fellowship for his proposed research aiming to further the understanding of using two new virus-based treatments to enhance the outcomes of brain tumour patients.

This research was completed in the summer of 2012 with some outstanding outcomes.

What we Know as a Result of the Research Fellowship

Dr. Alain: "My studies uncovered a potentially valuable biomarker that can determine the therapeutic efficacy of mTOR inhibitors in the clinic, and provided the stepping-stones in understanding the mechanisms by which synergy occurs between mTOR inhibitors and oncolytic viruses to eliminate brain tumours."

What are the Next Steps for this Research Area?

Dr. Alain: "With ongoing clinical trials including phase three trials using oncolytic viruses for the treatment of cancers, as well as the asTORi presently undergoing extensive clinical developments, their synergistic combination may represent an exciting novel strategy to treat brain tumours. Further research into molecular targets and mechanisms involved are in progress, with the hope that this approach will eventually be explored in the clinical setting."

Next Steps for Dr. Alain

Dr. Alain: "The William Donald Nash Brain Tumour Research Fellowship has had a great impact on my career. It allowed me to pursue my research in the area of brain tumours, which I hope to continue as an independent investigator."
 

Read Dr. Alain's full report as a pdf or on this page.

 

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