2013 Researcher Dr. Aru Narendran

A Virus to Kill by: Double-deleted Vaccinia virus (VVdd) as a novel therapeutic agent for a defiant pediatric brain tumour

Dr Aru Narendran
University of Calgary, Alberta Children’s Hospital, Calgary, AB
Award: $25,000

Dr. Narandran's project is funded through the generosity of the Pink Warrior Foundation, Saskatoon, SK

 

Project Summary:

Atypical teratoid rhabdoid tumour of the central nervous system (CNS AT/RT) is a highly malignant brain tumour of infancy that often causes death within months. In spite of multiple treatment regimens consisting of surgery, radiation and chemotherapy, with or without stem cell transplant, only a few long-term survivors of CNS AT/RT have been reported.

Hence, research is urgently needed to identify effective new agents and novel therapeutic approaches for these children. Recent studies have shown evidence for the use of oncolytic viruses (OVs) as a means to deliver effective cytotoxic therapy to tumors that have become resistant to conventional treatment approaches.

The idea behind this approach is to develop viruses that can replicate and cause the cancer cells to break down while leaving non-malignant cells unaffected. Vaccinia virus (VV) is a type of OV with several desirable attributes to be selected as a therapeutic agent, including a highly acceptable safety profile from its use as a vaccine in the small pox eradication program and its ability to positively alter specific immune responses. Based on our encouraging preliminary data, we propose to investigate the potential of a modified (double deleted) vaccinia virus in preclinical studies for the treatment of AT/RT.

Read more about Dr. Narendran in this story ...

“Your child has a brain tumour.” – Six shocking words no parent should ever have to hear, and the impact of which can be devastating. For Calgary researcher Dr. Aru Narendran, knowing first-hand what the brain tumour journey can mean for families motivates him to spend his days in a lab. There he and his team search for a cure for one of the most fatal types of malignant pediatric brain tumour, atypical teratoid/rhabdoid (AT/RT). Absolute in his determination to eradicate childhood cancers, Dr. Narendran has a few choice words of his own for the illness. “I don’t see a reason why we can’t cure every single kid with cancer. We cured polio and other diseases completely, so it’s just a matter of time. It will happen.” Read the rest of this story...

<back to 2013 Grant Awardees

 

 


 

 

Share This

Featured Story

Hats for Hope

Today, 8 Canadians will learn they have brain cancer. That's 3,000 Canadians each year. That's why we have launched Hats for Hope a nation-wide brain cancer awareness campaign and are calling on all Canadians to pledge support for brain cancer research. Join us in International Brain Tumour Awareness Week, October 20 - 27, 2018, or on October 24, 2018 – the first Brain Cancer Awareness Day in Canada – by wearing a hat, taking a selfie or group photo, and sharing it on social using #HatsForHope

Learn more

Spotlight

Childhood Brain Tumour Signs & Symptoms

Earlier this year, you gave us your feedback in a survey on brain tumour signs and symptoms. One of the things we did with that survey...

Learn more

Anthony's Story is Our Story

I would like to take the opportunity to share "our" story. It’s actually my best friend Anthony's story, but I use the term "our"...

Learn more

Upcoming Events

  • 24/Oct/2018: Ottawa Support Group: Meets at the Maplesoft Centre at 1500 Alta Vista Drive, Ottawa, ON.... Learn more >
  • 25/Oct/2018: Virtual Support Group East: Virtual Support Group for Eastern Canada... Learn more >
  • 27/Oct/2018: National Conference - Montreal: Hôtel Ruby Foo's, Montreal, QC & diffusion en direct... Learn more >
  • 27/Oct/2018: SUPERKIDS - A Quest to End Brain Tumours: CitiPlaza, London, ON... Learn more >
View All Events >
Thank you to the donors whose contributions make this website and all programs, services and research possible.

Copyright © 2018 Brain Tumour Foundation of Canada. Charitable Registration #BN118816339RR0001