2013 Researcher Dr. Kevin Petrecca

Development of novel therapeutics to prevent brain cancer invasion

Dr Kevin Petrecca
Dr. Kevin Petrecca
Montreal Neurological Institute and Hospital, Montreal, QC
Award: $25,000

Dr. Petrecca's project is funded in memory of Richard N. Patina


Project Summary:

Glioblastoma (GBM) is the most common and invasive adult brain cancer, and average survival is less than two years. Cancer cell invasion into normal brain is a hallmark of GBM and is major contributor to rapid treatment failure, yet our understanding of the mechanisms that regulate this process remains poorly understood.

Since GBM invasion leads to recurrence near the surgical resection margin in greater than 85% of cases, catheter-based local delivery of anti-invasive therapeutics directly to this area allows for maximal dosing and minimal toxicity. Catheter-based delivery of antisense oligonucleotides is already a globally approved treatment for GBM.

We have identified “downregulated in renal cell carcinoma” (DRR), a tumour suppressor gene, as a driver of GBM invasion.  The goal of this research project is to develop an innovative therapeutic approach to prevent brain cancer invasion. We will test the effectiveness of antisense oligonucleotides targeting DRR in preventing brain cancer invasion in a preclinical mouse model of the disease.

<back to 2013 Grant Awardees

Share This

Featured Story

Kate's Mum's Story

"May 2006 is a month I will never forget. That was the moment that everything became before the cancer, and after the cancer. It was a mark in time that would forever change my family"... Read more about Kate's Mum's story from her diagnosis of glioblastoma in 2006 and how Mum has beaten the odds to still be here today.

Learn more


Roy and the Gamma Knife – A Happy Tale

I had headaches, almost daily, for 10 years or more. It was a rare day if I did not have a headache. I used to joke that I should own...

Learn more

Courtney’s Story of Stability

Stability. It’s a strange concept when you have what it known to be a progressive, life long illness. You hear the words, “Your tumour...

Learn more

Upcoming Events

  • 24/Jul/2018: Groupe de soutien virtuel: Un groupe de soutien virtuel pour personnes touchées par une tumeur... Learn more >
  • 25/Jul/2018: Toronto Support Group: Meets at Wellspring Westerkirk House at Sunnybrook, Toronto, ON... Learn more >
  • 29/Jul/2018: 11th Annual Black Diamond Car Show Presented by Thumbs Up: Black Diamond, AB... Learn more >
  • 02/Aug/2018: Ajax Support Group: Meets at St. Paul's United Church, 65 King's Crescent, Ajax, ON... Learn more >
View All Events >
Thank you to the donors whose contributions make this website and all programs, services and research possible.

Copyright © 2018 Brain Tumour Foundation of Canada. Charitable Registration #BN118816339RR0001