2013 Researcher Dr. Kevin Petrecca

Development of novel therapeutics to prevent brain cancer invasion

Dr Kevin Petrecca
Dr. Kevin Petrecca
Montreal Neurological Institute and Hospital, Montreal, QC
Award: $25,000

Dr. Petrecca's project is funded in memory of Richard N. Patina


Project Summary:

Glioblastoma (GBM) is the most common and invasive adult brain cancer, and average survival is less than two years. Cancer cell invasion into normal brain is a hallmark of GBM and is major contributor to rapid treatment failure, yet our understanding of the mechanisms that regulate this process remains poorly understood.

Since GBM invasion leads to recurrence near the surgical resection margin in greater than 85% of cases, catheter-based local delivery of anti-invasive therapeutics directly to this area allows for maximal dosing and minimal toxicity. Catheter-based delivery of antisense oligonucleotides is already a globally approved treatment for GBM.

We have identified “downregulated in renal cell carcinoma” (DRR), a tumour suppressor gene, as a driver of GBM invasion.  The goal of this research project is to develop an innovative therapeutic approach to prevent brain cancer invasion. We will test the effectiveness of antisense oligonucleotides targeting DRR in preventing brain cancer invasion in a preclinical mouse model of the disease.

<back to 2013 Grant Awardees

Share This

Featured Story

Childhood Brain Tumour Signs & Symptoms

Earlier this year, you gave us your feedback in a survey on brain tumour signs and symptoms. One of the things we did with that survey was to compile a list of the most common signs & symptoms for children. Now, as part of Childhood Cancer Awareness Month, we are sharing compelling quotes from that survey and urging you to share them with this link to see the symptoms: www.braintumour.ca/symptoms. Thank you!

Learn more


Anthony's Story is Our Story

I would like to take the opportunity to share "our" story. It’s actually my best friend Anthony's story, but I use the term "our"...

Learn more

Kate's Mum's Story

"May 2006 is a month I will never forget. That was the moment that everything became before the cancer, and after the cancer. It was a...

Learn more

Upcoming Events

  • 18/Oct/2018: Rock Your Locks 2018: Abbey Park High School, Oakville, ON... Learn more >
  • 18/Oct/2018: Burlington and Hamilton Support Group: Meets at Aldershot Public Library (550 Plains Road East), Burlington, ON... Learn more >
  • 19/Oct/2018: National Conference - Evening Celebration: Sheraton Toronto Airport Hotel and Conference Centre, Toronto, ON... Learn more >
  • 20/Oct/2018: National Conference - Toronto: Toronto ON, and via live streaming across Canada... Learn more >
View All Events >
Thank you to the donors whose contributions make this website and all programs, services and research possible.

Copyright © 2018 Brain Tumour Foundation of Canada. Charitable Registration #BN118816339RR0001