2014 Researcher Dr. Pejman Jabehdar Maralan

"Quantitative blood oxygenation level dependent (qBOLD) MR imaging of glioblastoma multiforme for assessment of tumour hypoxia"

Dr. Pejman Jabehdar Maralani; Lecturer, Staff Neuroradiologist, Medical Imaging, University of Toronto, Sunnybrook Health Sciences Centre

 

Project Summary:

Glioblastoma multiforme (GBM) is the most common primary malignant brain neoplasm in adults. Despite recent diagnostic and therapeutic advances, including aggressive surgical resection and chemoradiation, the prognosis of GBM has improved only slightly over the past two decades, with median survival approximately 15 months.

Tumour hypoxia is a feature of GBM that contributes to poor outcome through multiple mechanisms such as:

1) overexpression of enzymes that play roles in temozolomide resistance, the main chemotherapeutic agent in GBM and

2) increase expression of cancer stem cells which are more resistant to radiation.

Hypoxic regions of the tumour are associated with higher rates of progression and recurrence. In this study we will use advanced MRI techniques to non-invasively measure oxygenation in GBM. We take advantage of physical characteristics of Ferumoxytol which is an iron supplement and utilize two recent technical advances not previously used in human tumours to quantitatively measure oxygenation in GBM.

Prior knowledge of hypoxia can assist in prognostication and individualization of treatment planning with a special focus on hypoxic regions by targeted radiation dose or regimen modulation; consideration of more intensive chemotherapy regimens; more aggressive and targeted surgical resection and closer short-term clinical and imaging follow-ups.

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