{"id":4705,"date":"2019-10-07T12:45:23","date_gmt":"2019-10-07T16:45:23","guid":{"rendered":"https:\/\/www.braintumour.ca\/research_recipients\/shane-harding-research-grant-2019\/"},"modified":"2021-09-09T17:12:17","modified_gmt":"2021-09-09T21:12:17","slug":"shane-harding-subvention-de-recherche-2019","status":"publish","type":"research_recipients","link":"https:\/\/www.braintumour.ca\/fr\/laureats_de_la_recherche\/shane-harding-subvention-de-recherche-2019\/","title":{"rendered":"Shane Harding – Subvention de recherche – 2019"},"content":{"rendered":"

Shane Harding, Centre du cancer Princess Margaret<\/strong><\/p>\n

Titre du projet :<\/strong> Toxicit\u00e9 c\u00e9r\u00e9brale induite par la radioth\u00e9rapie : Une base m\u00e9canistique et une opportunit\u00e9 th\u00e9rapeutique<\/em><\/p>\n

R\u00e9sum\u00e9 du projet :<\/strong><\/p>\n

\"Shane<\/p>\n

De nombreux cancers du cerveau sont des diagnostics tragiques dont les taux de survie sont faibles, m\u00eame avec une chirurgie, une radioth\u00e9rapie et une chimioth\u00e9rapie agressives. Les effets secondaires de ces traitements peuvent avoir de profondes r\u00e9percussions sur la qualit\u00e9 de vie des patients. Nous avons r\u00e9cemment identifi\u00e9 une voie mol\u00e9culaire qui est activ\u00e9e par la radioth\u00e9rapie pour provoquer des signaux inflammatoires. Ces signaux d\u00e9clenchent le syst\u00e8me immunitaire et renforcent un nouveau traitement passionnant appel\u00e9 immunoth\u00e9rapie. Il est important de noter que ces m\u00eames signaux sont \u00e9galement pr\u00e9sents chez les patients atteints de maladies g\u00e9n\u00e9tiques sp\u00e9cifiques qui entra\u00eenent des d\u00e9ficits neurologiques. Cela sugg\u00e8re qu’il est important d’\u00e9quilibrer soigneusement les signaux produits par les radiations pour maximiser la gu\u00e9rison des tumeurs et minimiser la toxicit\u00e9.<\/p>\n

Dans ce projet, nous allons tester notre pr\u00e9diction selon laquelle les signaux inflammatoires provoqu\u00e9s par la radioth\u00e9rapie endommagent le cerveau et entra\u00eenent des effets secondaires associ\u00e9s. Nous avons 2 objectifs majeurs : (1) identifier de nouvelles fa\u00e7ons de suivre ou de pr\u00e9dire la toxicit\u00e9 pendant la radioth\u00e9rapie du cerveau afin de mieux contr\u00f4ler leur d\u00e9veloppement et (2) d\u00e9terminer si une nouvelle classe de m\u00e9dicaments ciblant les voies mol\u00e9culaires activ\u00e9es par la radioth\u00e9rapie peut pr\u00e9venir les effets secondaires. L’ensemble de cette proposition vise \u00e0 trouver de nouveaux moyens d’am\u00e9liorer le traitement du cancer du cerveau et la qualit\u00e9 de vie des patients.<\/p>\n

Lisez la mise \u00e0 jour \u00e0 mi-parcours de Shane pour 2020 ici (en anglais).<\/strong><\/a><\/p>\n

Ce que recevoir ce prix signifie pour Shane :<\/strong><\/p>\n

\u00ab\u00a0Ce soutien de la Fondation canadienne des tumeurs c\u00e9r\u00e9brales est essentiel \u00e0 la poursuite de notre objectif d’am\u00e9liorer la radioth\u00e9rapie chez les patients atteints de tumeurs c\u00e9r\u00e9brales en am\u00e9liorant la r\u00e9ponse au traitement et en minimisant la toxicit\u00e9.\u00a0\u00bb<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Shane Harding, Princess Margaret Cancer Centre. 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