{"id":4709,"date":"2018-08-17T12:08:48","date_gmt":"2018-08-17T16:08:48","guid":{"rendered":"https:\/\/www.braintumour.ca\/research_recipients\/qi-zhang-research-grant-2018\/"},"modified":"2021-09-09T17:16:19","modified_gmt":"2021-09-09T21:16:19","slug":"qi-zhang-subvention-de-recherche-2018","status":"publish","type":"research_recipients","link":"https:\/\/www.braintumour.ca\/fr\/laureats_de_la_recherche\/qi-zhang-subvention-de-recherche-2018\/","title":{"rendered":"Qi Zhang – Subvention de recherche – 2018"},"content":{"rendered":"

Qi Zhang, Centre des sciences de la sant\u00e9 de London<\/strong><\/p>\n

Titre du projet :<\/strong> D\u00e9couverte de biomarqueurs de cancer du poumon pr\u00e9dictifs de m\u00e9tastases c\u00e9r\u00e9brales<\/em><\/p>\n

R\u00e9sum\u00e9 du projet :<\/strong><\/p>\n

\"Qi<\/p>\n

Un cancer provenant d’autres parties du corps peut se propager au cerveau. Ce ph\u00e9nom\u00e8ne est connu sous le nom de m\u00e9tastase c\u00e9r\u00e9brale. Le cancer du poumon est le cancer le plus courant qui se propage au cerveau. Le diagnostic de m\u00e9tastase c\u00e9r\u00e9brale est g\u00e9n\u00e9ralement pos\u00e9 \u00e0 un stade tardif, avec des complications tr\u00e8s graves. Nous comprenons mal le processus de m\u00e9tastase c\u00e9r\u00e9brale et notre capacit\u00e9 \u00e0 d\u00e9tecter et \u00e0 traiter un cancer qui s’est propag\u00e9 au cerveau est limit\u00e9e. Le cerveau poss\u00e8de des m\u00e9canismes de d\u00e9fense uniques pour se prot\u00e9ger de l’invasion des cellules tumorales. Pour que les cellules canc\u00e9reuses puissent p\u00e9n\u00e9trer dans le cerveau et y survivre, elles doivent franchir plusieurs \u00e9tapes et briser ces d\u00e9fenses. Dans des mod\u00e8les animaux et des \u00e9tudes de culture cellulaire, les chercheurs ont r\u00e9cemment d\u00e9couvert que certaines cellules canc\u00e9reuses \u00e9taient capables de fabriquer de petites mol\u00e9cules pour les aider \u00e0 franchir ces d\u00e9fenses.<\/p>\n

Dans notre \u00e9tude, nous examinerons des \u00e9chantillons de patients atteints de cancer du poumon, pr\u00e9lev\u00e9s \u00e0 diff\u00e9rents moments, afin d’identifier les changements qui se produisent dans les cellules canc\u00e9reuses du poumon pour permettre aux cellules de se d\u00e9placer et d’\u00e9chapper aux m\u00e9canismes de d\u00e9fense du cerveau. Nous utiliserons une technique mol\u00e9culaire de pointe, les micror\u00e9seaux, pour d\u00e9couvrir les mol\u00e9cules sp\u00e9cifiquement exprim\u00e9es par les cellules canc\u00e9reuses qui se d\u00e9placent vers le cerveau. L’objectif principal de notre recherche, qui arrive \u00e0 point nomm\u00e9, est d’identifier les r\u00e9gulateurs cl\u00e9s qui facilitent les m\u00e9tastases c\u00e9r\u00e9brales afin de pouvoir les d\u00e9tecter et les traiter.<\/p>\n

Ce que recevoir ce prix signifie pour Qi :<\/strong><\/p>\n

\u00ab\u00a0En tant que nouveau chercheur clinicien, la subvention de recherche de la Fondation canadienne des tumeurs c\u00e9r\u00e9brales me permettra d’\u00e9tablir un programme de recherche sur l’\u00e9tude des tumeurs m\u00e9tastatiques c\u00e9r\u00e9brales. Notre objectif est de d\u00e9velopper un panel de biomarqueurs mol\u00e9culaires sp\u00e9cifiques pour la pr\u00e9vention, la d\u00e9tection et le traitement des m\u00e9tastases c\u00e9r\u00e9brales du cancer du poumon.\u00a0\u00bb<\/p>\n

Vous pouvez lire l’\u00e9tude ici :<\/p>\n

Zheng et al. – 2020 – Overexpression of Long Noncoding RNA HOTAIR Is a Unique Epigenetic Characteristic of Myxopapillary Ependymoma<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Qi Zhang, London Health Sciences Centre. Project Title: \u201cDiscovering Lung Cancer Biomarkers Predictive of Brain Metastasis\u201d<\/p>\n","protected":false},"featured_media":944,"menu_order":0,"template":"","research_recipient_type":[512],"class_list":["post-4709","research_recipients","type-research_recipients","status-publish","has-post-thumbnail","hentry","research_recipient_type-subvention-de-recherche"],"acf":[],"yoast_head":"\nQi Zhang - Subvention de recherche - 2018 - Fondation canadienne des tumeurs c\u00e9r\u00e9brales<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.braintumour.ca\/fr\/laureats_de_la_recherche\/qi-zhang-subvention-de-recherche-2018\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Qi Zhang - Subvention de recherche - 2018\" \/>\n<meta property=\"og:description\" content=\"Qi Zhang, London Health Sciences Centre. 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