{"id":4716,"date":"2017-07-21T15:32:03","date_gmt":"2017-07-21T19:32:03","guid":{"rendered":"https:\/\/www.braintumour.ca\/research_recipients\/thomas-klonisch-research-grant-2017\/"},"modified":"2021-09-09T17:57:12","modified_gmt":"2021-09-09T21:57:12","slug":"thomas-klonisch-research-grant-2017","status":"publish","type":"research_recipients","link":"https:\/\/www.braintumour.ca\/fr\/laureats_de_la_recherche\/thomas-klonisch-research-grant-2017\/","title":{"rendered":"Thomas Klonisch \u2013 Bourse de recherche 2017"},"content":{"rendered":"<p>Thomas Klonisch, Professor &amp; Head, Human Anatomy and Cell Science, University of Manitoba<\/p>\n<h5>\u00ab\u00a0Novel minimally-invasive immune-proteome biomarker strategy for Glioblastoma\u00a0\u00bb<\/h5>\n<h3>Project Summary<\/h3>\n<p style=\"font-weight: 400;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-2070\" src=\"https:\/\/braintumour.ca\/wp-content\/uploads\/2019\/11\/Thomas-Klonisch-e1573158855498-300x272.png\" alt=\"Thomas Klonisch \u2013 Research Grant \u2013 2017\" width=\"300\" height=\"272\" srcset=\"https:\/\/www.braintumour.ca\/wp-content\/uploads\/2019\/11\/Thomas-Klonisch-e1573158855498-300x272.png 300w, https:\/\/www.braintumour.ca\/wp-content\/uploads\/2019\/11\/Thomas-Klonisch-e1573158855498.png 349w\" sizes=\"auto, (max-width: 639px) 98vw, (max-width: 1199px) 64vw, 300px\" \/>There is an urgent need for the rapid identification of protein and immunological biomarkers which are indicative of brain tumours, permit early diagnosis, and monitor treatment options and responses. Ideally, such assays are minimally-invasive and detect circulating oncological and immunological biomarkers from blood samples. Nowhere is this more important than in the early diagnosis and monitoring of highly malignant and rapidly growing glioblastoma (GBM) which constitute about 60% of all primary brain tumours and has one of the worst 5-year survival rates among all cancers. Currently, there is no early diagnostic test for GBM.<\/p>\n<p style=\"font-weight: 400;\">We have established two minimally invasive assays for the identification of plasma-based predictive and\/or prognostic proteome and circulating immune cell signatures from a single patient blood sample. These robust high content assays include the proteomic SOMA scan assay and a multicolour flow cytometry detection several immune cell subtypes circulating within the blood. The combination of both assays translates into a new strategy for clinical monitoring of GBM patients.<\/p>\n<p style=\"font-weight: 400;\">The primary goal of our proposal is to identify plasma-derived protein and immune cell signatures that are suitable for early non-invasive diagnosis of GBM, can serve as response predictor or differentiator of pseudo-progression vs real progression, and indicate GBM recurrences.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thomas Klonisch, University of Manitoba. Project: \u00ab\u00a0Novel minimally-invasive immune-proteome biomarker strategy for Glioblastoma\u00a0\u00bb<\/p>\n","protected":false},"featured_media":2071,"menu_order":0,"template":"","research_recipient_type":[283,285],"class_list":["post-4716","research_recipients","type-research_recipients","status-publish","has-post-thumbnail","hentry","research_recipient_type-fellowship-fr","research_recipient_type-grant-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Thomas Klonisch \u2013 Bourse de recherche 2017 - Fondation canadienne des tumeurs c\u00e9r\u00e9brales<\/title>\n<meta name=\"description\" content=\"Thomas Klonisch, University of Manitoba. Project: &quot;Novel minimally-invasive immune-proteome biomarker strategy for Glioblastoma&quot;\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.braintumour.ca\/fr\/laureats_de_la_recherche\/thomas-klonisch-research-grant-2017\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Thomas Klonisch \u2013 Bourse de recherche 2017\" \/>\n<meta property=\"og:description\" content=\"Thomas Klonisch, University of Manitoba. 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