Project Summary:<\/h3>\nIntracranial germ cell tumours (IGCT) affect both children and adults. \u00a0The treatment of IGCT in adolescents and young adults (AYA) is extrapolated from literature on children, due to the small proportion of AYA in most studies. \u00a0Treatment of IGCT involves radiotherapy (RT) alone or a combination of RT and chemotherapy. \u00a0RT is associated with significant late complications. \u00a0Chemotherapy alone, however is insufficient due to high rates of disease recurrence. \u00a0The reduction of the dose and volume of RT is being investigated in studies that are largely focused on children. \u00a0On the other hand, published and ongoing studies to guide management of IGCT in AYA are scarce, and therefore, treatment patterns in this group are variable.<\/div>\n<\/div>\nThe first part of this study is a national survey of physicians to assess treatment patterns of IGCT in AYA. Secondly, the medical records of AYA treated for IGCT in Toronto and British Columbia will be reviewed to determine outcomes and complications according to treatment approach. \u00a0Lastly, survivors will participate in a prospective evaluation of long-term complications and quality of life. The results will provide invaluable guidance in the management of ICGT in AYA, and aid in development of standard treatment guidelines for this population.<\/div>\nAndrea Lo describes what the research means to her:<\/h3>\n![\"Andrea](\"https:\/\/braintumour.ca\/wp-content\/uploads\/2019\/10\/AndreaLo-300x198.jpg\")
\u00ab\u00a0Being awarded the Nazira Mamdani Brain Tumour Research Fellowship means I have been generously granted the opportunity to grow and develop as a clinician investigator. I am passionate about research, and I look forward to making it a central part of my long-term career. This funding will support a study that will improve our understanding of intracranial germ cell tumours in adolescents and young adults, and will be an important step towards optimizing treatment and quality of life for patients affected by this disease. I am sincerely grateful to the family of Nazira Mamdani and the Brain Tumour Foundation of Canada for their contribution towards advancing medical knowledge and improving the lives of those affected by brain tumours.\u00a0\u00bb<\/div>\nFrom the first report:<\/h3>\nThe data collection and analysis of Part I (Canadian Patterns of Practice) and Part II (Outcomes and complications in the management of intracranial germ cell tumours) have been completed. Results have been submitted as abstracts to several conferences and presented as both poster and oral presentations (see report). Manuscripts for Part I and Part II will be written over the next 3 months. Part III of the study will be started next month and completed over the ensuing 14-15 months, including data collection, analysis and publication.\u00a0Read the first year report (PDF).<\/a><\/div>\nFrom the final report, January 2019:<\/h3>\n
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The first part of this study is a national survey of physicians to assess treatment patterns of IGCT in AYA. Secondly, the medical records of AYA treated for IGCT in Toronto and British Columbia will be reviewed to determine outcomes and complications according to treatment approach. \u00a0Lastly, survivors will participate in a prospective evaluation of long-term complications and quality of life. The results will provide invaluable guidance in the management of ICGT in AYA, and aid in development of standard treatment guidelines for this population.<\/div>\nAndrea Lo describes what the research means to her:<\/h3>\n
Andrea Lo describes what the research means to her:<\/h3>\n\u00ab\u00a0Being awarded the Nazira Mamdani Brain Tumour Research Fellowship means I have been generously granted the opportunity to grow and develop as a clinician investigator. I am passionate about research, and I look forward to making it a central part of my long-term career. This funding will support a study that will improve our understanding of intracranial germ cell tumours in adolescents and young adults, and will be an important step towards optimizing treatment and quality of life for patients affected by this disease. I am sincerely grateful to the family of Nazira Mamdani and the Brain Tumour Foundation of Canada for their contribution towards advancing medical knowledge and improving the lives of those affected by brain tumours.\u00a0\u00bb<\/div>\nFrom the first report:<\/h3>\nThe data collection and analysis of Part I (Canadian Patterns of Practice) and Part II (Outcomes and complications in the management of intracranial germ cell tumours) have been completed. Results have been submitted as abstracts to several conferences and presented as both poster and oral presentations (see report). Manuscripts for Part I and Part II will be written over the next 3 months. Part III of the study will be started next month and completed over the ensuing 14-15 months, including data collection, analysis and publication.\u00a0Read the first year report (PDF).<\/a><\/div>\nFrom the final report, January 2019:<\/h3>\n
\u00ab\u00a0Being awarded the Nazira Mamdani Brain Tumour Research Fellowship means I have been generously granted the opportunity to grow and develop as a clinician investigator. I am passionate about research, and I look forward to making it a central part of my long-term career. This funding will support a study that will improve our understanding of intracranial germ cell tumours in adolescents and young adults, and will be an important step towards optimizing treatment and quality of life for patients affected by this disease. I am sincerely grateful to the family of Nazira Mamdani and the Brain Tumour Foundation of Canada for their contribution towards advancing medical knowledge and improving the lives of those affected by brain tumours.\u00a0\u00bb<\/div>\n