medulloblastoma<\/a> (MB) is the most frequent malignant pediatric brain tumour. While MBs characterized by active sonic hedgehog (Shh) signaling have been of therapeutic interest, treatment-resistance has posed significant challenges.<\/p>\nSince MB brain tumour-initiating cells prospectively identify, characterize, and target treatment-refractory BTICs in Shh-dependent MB. In correlating the gene expression profile of 325 human MBs with their overall clinical outcome, we identified the stem cell gene Sox2 as an independent marker of treatment-refractory Shh MB.<\/p>\n
By modifying the Children\u2019s Oncology Group (COG) MB protocol for our BTIC human-mouse xenograft model, we will treat Shh-dependent MB BTIC-bearing mice with radio-and chemotherapy and assess the corresponding increase in Sox2+ cells with small molecule inhibitors identified in our pathway network analysis of these cells.<\/p>\n
Given the current research emphasis on treatment-na\u00efve tumours, we hope our model will account for the evolution of cells over the course of therapy and provide an opportunity to selectively target and improve the survival of treatment-resistant Group 2 MB patients.<\/p>\n","protected":false},"excerpt":{"rendered":"
Sheila Singh, McMaster University. Project: \u00ab\u00a0Therapeutic targeting of Sox2+ treatment-refractory stem cells in sonic hedgehog-dependent pediatric medulloblastoma\u00a0\u00bb<\/p>\n","protected":false},"featured_media":2115,"menu_order":0,"template":"","research_recipient_type":[285],"class_list":["post-4740","research_recipients","type-research_recipients","status-publish","has-post-thumbnail","hentry","research_recipient_type-grant-fr"],"acf":[],"yoast_head":"\n
Dr. Sheila Singh \u2013 Bourse de recherche 2014 - Fondation canadienne des tumeurs c\u00e9r\u00e9brales<\/title>\n<meta name=\"description\" content=\"Sheila Singh, McMaster University. Project: "Therapeutic targeting of Sox2+ treatment-refractory stem cells in sonic hedgehog-dependent pediatric medulloblastoma"\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.braintumour.ca\/fr\/laureats_de_la_recherche\/dr-sheila-singh-research-grant-2014\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dr. Sheila Singh \u2013 Bourse de recherche 2014\" \/>\n<meta property=\"og:description\" content=\"Sheila Singh, McMaster University. 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Brain tumours represent the leading cause of childhood cancer mortality, of which medulloblastoma<\/a> (MB) is the most frequent malignant pediatric brain tumour. While MBs characterized by active sonic hedgehog (Shh) signaling have been of therapeutic interest, treatment-resistance has posed significant challenges.<\/p>\n