{"id":4743,"date":"2014-08-21T16:27:09","date_gmt":"2014-08-21T20:27:09","guid":{"rendered":"https:\/\/www.braintumour.ca\/research_recipients\/dr-john-kelly-research-grant-2014\/"},"modified":"2020-05-20T19:03:45","modified_gmt":"2020-05-20T23:03:45","slug":"dr-john-kelly-research-grant-2014","status":"publish","type":"research_recipients","link":"https:\/\/www.braintumour.ca\/fr\/laureats_de_la_recherche\/dr-john-kelly-research-grant-2014\/","title":{"rendered":"Dr. John Kelly \u2013 Bourse de recherche 2014"},"content":{"rendered":"<p>Dr. John Kelly; Neurosurgeon and Assistant Professor, Clinical Neurosciences, University of Calgary<\/p>\n<h5>Project Title: \u00ab\u00a0Combinatorial treatment of glioblastoma initiating cells with microglial cytokines and STAT3 inhibition\u00a0\u00bb<\/h5>\n<h3 class=\"underlined\">Project Summary<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-2101\" src=\"https:\/\/braintumour.ca\/wp-content\/uploads\/2019\/11\/Dr-John-Kelly-2014Grant-e1573162148607.jpg\" alt=\"John Kelly \u2013 Research Grant \u2013 2015\" width=\"162\" height=\"204\" \/>Glioblastoma (GBM) is the most common and most aggressive primary brain tumour, and it harbours a dismal prognosis. GBMs have been shown to contain brain tumour initiating cells (BTICs), a subpopulation of tumour cells with the capacity to proliferate and generate the other cells within a tumour. BTICs are powerful mediators of immunosuppression through regulation of immune cell responses and they are highly resistant to treatment leading inevitably to tumour recurrence. We seek to reduce the immunosuppressive abilities of GBM BTICs while simultaneously targeting them with growth inhibitory microglial cytokines.<\/p>\n<p>We hope to demonstrate efficacy of this approach and begin to understand the mechanisms by which these strategies impact GBM BTICs. This work will form the basis for further preclinical studies that attempt to sway the tumour-immune interactions in favour of microglia in order to suppress GBMs.<\/p>\n<p>This project may help develop a novel combinatorial therapeutic approach whereby BTIC driven immunosuppression is inhibited and compromised innate immunity is simultaneously reactivated in order to improve the prognosis for patients with GBM.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. John Kelly; University of Calgary. Project: \u00ab\u00a0Combinatorial treatment of glioblastoma initiating cells with microglial cytokines and STAT3 inhibition\u00a0\u00bb<\/p>\n","protected":false},"featured_media":2102,"menu_order":0,"template":"","research_recipient_type":[285],"class_list":["post-4743","research_recipients","type-research_recipients","status-publish","has-post-thumbnail","hentry","research_recipient_type-grant-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Dr. John Kelly \u2013 Bourse de recherche 2014 - Fondation canadienne des tumeurs c\u00e9r\u00e9brales<\/title>\n<meta name=\"description\" content=\"Dr. John Kelly; University of Calgary. 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