{"id":4753,"date":"2013-05-10T13:41:32","date_gmt":"2013-05-10T17:41:32","guid":{"rendered":"https:\/\/www.braintumour.ca\/research_recipients\/dr-sabine-mai-research-grant-2013\/"},"modified":"2020-05-20T19:05:14","modified_gmt":"2020-05-20T23:05:14","slug":"dr-sabine-mai-research-grant-2013","status":"publish","type":"research_recipients","link":"https:\/\/www.braintumour.ca\/fr\/laureats_de_la_recherche\/dr-sabine-mai-research-grant-2013\/","title":{"rendered":"Dr. Sabine Mai – Bourse de recherche 2013"},"content":{"rendered":"

Dr. Sabine Mai, Manitoba Institute of Cell Biology, Winnipeg, MB<\/p>\n

Characterization of ependymomas into favourable and non-favourable groups based on their 3D nuclear telomere profiles.<\/p>\n

Project Summary:<\/h3>\n

\"SabineThe proposed study focuses on ependymoma, a childhood brain tumour. At diagnosis, it is not possible to know which child will respond to treatment and which child will recur, i.e. if prognosis is favourable or non-favourable. We have developed quantitative tools that may allow for the distinction of good and poor responders at diagnosis.<\/p>\n

These tools involve three-dimensional (3D) imaging of telomeres. Telomeres are the ends of chromosomes; they protect the chromosomes from damage and prevent recombination and fusion with other chromosomes (Mai, 2010). Telomere dysfunction therefore is associated with genomic instability and found in many cancers (Mai and Garini, 2006; Mai, 2010).<\/p>\n

The data obtained in this study are quantitatively measured, and the output is expected to be a 3D nuclear telomeric profile of each child\u2019s tumour, indicative of favourable or non-favourable disease and will, in the near future, enable for the first time a choice for specific treatments for each child\u2019s ependymoma.<\/p>\n","protected":false},"excerpt":{"rendered":"

Dr. Sabine Mai, Manitoba Institute of Cell Biology. Project: \u00ab\u00a0Characterization of ependymomas into favourable and non-favourable groups based on their 3D nuclear telomere profiles.\u00a0\u00bb<\/p>\n","protected":false},"featured_media":2213,"menu_order":0,"template":"","research_recipient_type":[285],"class_list":["post-4753","research_recipients","type-research_recipients","status-publish","has-post-thumbnail","hentry","research_recipient_type-grant-fr"],"acf":[],"yoast_head":"\nDr. Sabine Mai - Bourse de recherche 2013 - Fondation canadienne des tumeurs c\u00e9r\u00e9brales<\/title>\n<meta name=\"description\" content=\"Dr. Sabine Mai, Manitoba Institute of Cell Biology. 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