{"id":9453,"date":"2022-05-20T09:22:09","date_gmt":"2022-05-20T13:22:09","guid":{"rendered":"https:\/\/www.braintumour.ca\/research_recipients\/muhammadvaseem-shaikh-2022-2023-dunn-with-cancer-brain-tumour-research-fellowship\/"},"modified":"2022-06-02T14:11:33","modified_gmt":"2022-06-02T18:11:33","slug":"muhammadvaseem-shaikh-2022-2023-dunn-with-cancer-brain-tumour-research-fellowship","status":"publish","type":"research_recipients","link":"https:\/\/www.braintumour.ca\/fr\/laureats_de_la_recherche\/muhammadvaseem-shaikh-2022-2023-dunn-with-cancer-brain-tumour-research-fellowship\/","title":{"rendered":"Muhammadvaseem Shaikh \u2013 Bourse de recherche Dunn with Cancer 2022-2023"},"content":{"rendered":"<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-7450 size-medium\" src=\"https:\/\/www.braintumour.ca\/wp-content\/uploads\/2022\/05\/VaseemShaikh-Fellowship.jpg\" alt=\"\" width=\"600\" height=\"400\" \/>Muhammadvaseem Shaikh<\/strong><\/p>\n<p>Boursier de recherche postdoctorale \u00e0 l&rsquo;Universit\u00e9 McMaster, Hamilton, ON<\/p>\n<p><strong>Intitul\u00e9 du projet:<\/strong> \u00ab Immunoth\u00e9rapie CAR-T CD133 allog\u00e9nique, \u00ab pr\u00eate \u00e0 l&#8217;emploi \u00bb pour le glioblastome \u00bb<\/p>\n<p><strong>R\u00e9sum\u00e9 du projet:<\/strong><\/p>\n<p>Le glioblastome (GBM) est la tumeur maligne du cerveau la plus fr\u00e9quente. Malgr\u00e9 un traitement agressif, presque tous les patients rechutent 7 \u00e0 9 mois apr\u00e8s le diagnostic. L&rsquo;\u00e9chec de la th\u00e9rapie et les mauvais r\u00e9sultats des patients peuvent \u00eatre attribu\u00e9s \u00e0 une petite population de cellules connues sous le nom de cellules souches de glioblastome, qui \u00e9chappent au traitement et favorisent la r\u00e9cidive de la maladie. Les GSC sont plus particuli\u00e8rement identifi\u00e9es par la prot\u00e9ine de surface cellulaire CD133, dont il a \u00e9t\u00e9 d\u00e9montr\u00e9 pr\u00e9c\u00e9demment qu&rsquo;elle \u00e9tait associ\u00e9e \u00e0 des propri\u00e9t\u00e9s pro-tumorales, notamment la r\u00e9sistance au traitement, la croissance, le maintien, la progression et les m\u00e9tastases des tumeurs. <\/p>\n<p>Auparavant, dans le laboratoire Singh, nous avons d\u00e9velopp\u00e9 une th\u00e9rapie par cellules T, appel\u00e9e CAR-T, capable de reconna\u00eetre le CD133 pour induire la mort des cellules tumorales. Bien que cette th\u00e9rapie ait \u00e9t\u00e9 efficace dans nos mod\u00e8les animaux de GBM humain, d&rsquo;autres consid\u00e9rations doivent \u00eatre prises en compte sur la voie du d\u00e9veloppement clinique. \u00c0 l&rsquo;heure actuelle, les th\u00e9rapies CAR-T sont g\u00e9n\u00e9r\u00e9es \u00e0 partir de cellules T pr\u00e9lev\u00e9es sur des patients atteints de cancer. Cela soul\u00e8ve une myriade de pr\u00e9occupations, notamment la qualit\u00e9 des cellules T des patients, le temps et le co\u00fbt de fabrication, et sa disponibilit\u00e9 pour les patients dont la maladie progresse rapidement. Par cons\u00e9quent, pour contourner ce probl\u00e8me, nous souhaitons d\u00e9velopper et tester des cellules CAR-T d\u00e9riv\u00e9es de donneurs qui sont g\u00e9n\u00e9tiquement modifi\u00e9es pour une utilisation s\u00fbre chez les patients atteints de GBM.<\/p>\n<p><strong>Ce que l&rsquo;obtention de la bourse signifie pour moi:<\/strong><\/p>\n<p>Je suis profond\u00e9ment reconnaissant et extr\u00eamement honor\u00e9 d&rsquo;avoir re\u00e7u la bourse de recherche DUNN with Cancer sur les tumeurs c\u00e9r\u00e9brales, 2022-2024. Cette bourse contribuera \u00e0 financer mes recherches au laboratoire du Dr Sheila Singh pour d\u00e9couvrir de nouvelles th\u00e9rapies ciblant le glioblastome.<\/p>\n<p>Le glioblastome (GBM) est la tumeur maligne du cerveau la plus fr\u00e9quente. Malgr\u00e9 un r\u00e9gime de traitement agressif, presque tous les patients rechutent apr\u00e8s 7 \u00e0 9 mois, avec une survie m\u00e9diane de 14,6 mois et une survie \u00e0 cinq ans inf\u00e9rieure \u00e0 5 %. Il est absolument n\u00e9cessaire de d\u00e9velopper de meilleures th\u00e9rapies pour les GBM. Travailler au laboratoire Singh m&rsquo;a permis d&rsquo;\u00eatre en contact direct avec des patients atteints de GBM, et le fait de voir leur souffrance et leur courage m&rsquo;inspire et me motive \u00e0 travailler plus dur.<\/p>\n<p>Ce prix m&rsquo;aidera \u00e0 poursuivre mon travail de mise au point d&rsquo;immunoth\u00e9rapies pour les patients atteints de GBM, qui seraient disponibles sur les tablettes, ce qui r\u00e9duirait le d\u00e9lai avant le traitement et offrirait \u00e9galement des options th\u00e9rapeutiques plus puissantes. Elle m&rsquo;aidera \u00e9galement \u00e0 r\u00e9aliser mon r\u00eave de travailler avec des scientifiques, des biologistes du cancer et des neurochirurgiens de renomm\u00e9e mondiale. Ce prix m&rsquo;aide beaucoup \u00e0 progresser dans mon parcours professionnel et \u00e0 devenir un scientifique accompli. Enfin, j&rsquo;aimerais remercier la famille et les amis de DUNN with Cancer et la Fondation canadienne des tumeurs c\u00e9r\u00e9brales pour m&rsquo;avoir aid\u00e9 \u00e0 poursuivre mon r\u00eave d\u2019am\u00e9liorer le traitement des tumeurs c\u00e9r\u00e9brales.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Muhammadvaseem Shaikh Boursier de recherche postdoctorale \u00e0 l&rsquo;Universit\u00e9 McMaster, Hamilton, ON Intitul\u00e9 du projet: \u00ab Immunoth\u00e9rapie CAR-T CD133 allog\u00e9nique, \u00ab [&hellip;]<\/p>\n","protected":false},"featured_media":9439,"menu_order":0,"template":"","research_recipient_type":[283,553,554,559,560,561],"class_list":["post-9453","research_recipients","type-research_recipients","status-publish","has-post-thumbnail","hentry","research_recipient_type-fellowship-fr","research_recipient_type-glioblastoma-fr","research_recipient_type-2022-fr","research_recipient_type-mcmaster-university-fr","research_recipient_type-singh-lab-fr","research_recipient_type-dunn-with-cancer-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - 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