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April 2021 – UAB research: Modified herpes virus shows promise in treating pediatric brain tumors
“A modified herpes virus, alone and in combination with radiation, has been shown to be well tolerated with early signs of clinical effectiveness in pediatric patients with high-grade brain tumors, or gliomas, according to findings from researchers at the University of Alabama at Birmingham and Children’s of Alabama.”
March 2021 – Chemo for glioblastoma may work better in morning than evening
Patients treated with Temozolomide in the morning are experiencing longer survival rates than those who receive their treatment in the evening, studies show.
March 2021 – Hydrogel used to revert cancer cells back to cancer stem cells
A hydrogel developed at Hokkaido University, Japan, successfully reverted cancer cells back to cancer stem cells within 24 hours, in six different human cancer types.
March 2021 – The Tumour Microenvironment: Local Effects With Widespread Consequences
Despite the fact that the Tumour Micro-Environment (TME) develops locally, as its name suggests, it has important and far-reaching consequences.
March 2021 – Pediatric brain tumours can be classified using diffusion weighted imaging and machine learning
Diffusion weighted imaging and machine learning can successfully classify the diagnosis and characteristics of common types of pediatric brain tumours.
March 2021 – Sydney Researchers Identify Potential New Drug Treatment Developed by Aminex Therapeutics for Fatal Childhood Cancer
A new drug combination has shown ‘spectacularly effective’ results against DIPG in animal and 3D model testing.
March 2021 – New immunotherapy target discovered for malignant brain tumours
Scientists say they have discovered a potential new target for immunotherapy of malignant brain tumours – the CD161 molecule.
March 2021 – Brain tumours and COVID-19: the patient and caregiver experience
This is the first international survey completed with the purpose of identifying brain tumour patient and caregiver concerns due to COVID-19.
March 2021 –
Promising new approach to stop growth of brain cancer cells
“Researchers at Princess Margaret Cancer Centre, the Hospital for Sick Children (SickKids) and University of Toronto, showed that chemically inhibiting the enzyme PRMT5 can suppress the growth of glioblastoma cells.”
March 2021 – World-first study highlights potential of focused ultrasound in the detection of brain cancer biomarkers through liquid biopsy
“In a first-ever study, Sunnybrook researchers have demonstrated that MRI-guided focused ultrasound technology can improve the detection of brain cancer biomarkers with the temporary opening of the blood-brain barrier to aid liquid biopsy.”
March 2021 – This US startup is building tiny injectable robots to attack tumours
Science fiction come to life – California-based Bionaut Labs is aiming to be the first to create remote-controlled robots that can be implanted to tackle tumours. The goal is clinical trials by 2023.
March 2021 – UWindsor chemist designs alternate treatment for brain cancer
John Trant received a research grant of $50,000 from Brain Tumour Foundation of Canada to assist his work into nanoparticles that can get past the blood-brain barrier.
March 2021 – Medexus Announces Expanded Availability of Gleolan in Canada
After limited availability through Health Canada’s special access program, Gleolan is now available commercially in Canada. The imaging agent aids surgeons in the resection of brain tumours by making tumour tissue glow a different colour than normal, healthy brain tissue.
February 2021 – Kintara Therapeutics enrolls last patient in Phase 2 VAL-083 trial for recurrent glioblastoma multiforme
Kintara Therapeutics Inc has enrolled the final patient in the recurrent arm of its ongoing Phase 2 clinical glioblastoma multiforme (GBM) study of its VAL-083 drug.
February 2021 – Setting international standards in analyzing patient-reported outcomes and QOL endpoints
“An international multidisciplinary consortium, co-led by the European Organisation for Research and Treatment of Cancer (EORTC) and Boehringer Ingelheim (BI), has been convened to generate recommendations to standardize the use, analysis, and interpretation of patient reported outcome (PRO) data in cancer clinical trials.”
February 2021 – Researchers find potential new treatment for fatal childhood brain cancer
Researchers in Australia are reporting promising new findings to treat Diffuse Intrinsic Pontine Glioma (DIPG).
February 2021 – New drug targets for childhood cancer neuroblastoma identified
The discovery of a single cell behind childhood neuroblastoma has created new drug treatment opportunities.
February 2021 – Prolonged high dose use of hormone drug linked to increased brain tumour risk in women
A French study of more than 250,000 women has shown the drug cyproterone acetate is associated with an increased risk of developing a brain tumour.
January 2021 – Montreal researcher’s work could identify children at risk for cancer
“The work of a Montreal researcher could lead to identifying which children have a genetic predisposition to cancer, allowing them to be closely monitored and, hopefully, lead to an early diagnosis of the disease.”
January 2021 – Multimodal spectroscopy detects brain tumours in vivo
“Researchers in Italy have performed a proof-of-concept study showing that a combination of three different optical spectroscopic techniques has potential to improve the in vivo detection and delineation of malignant brain tumours and to guide their surgical removal.”
December 2020 – Brain cancer linked to tissue healing: U of T researchers
“The healing process that follows a brain injury – from trauma to infection and stroke – could spur tumour growth.”
December 2020 –
Anti-diarrhea drug may treat same type of brain cancer that killed Gord Downie: study
“A research group in at Goethe University Frankfurt found that the drug loperamide, sometimes sold under the brand name Imodium, can be used to induce cell death in glioblastoma cell lines.”
December 2020 –
Researchers identify the origin of a deadly brain cancer News
A research team from McGill University have discovered a gene needed for tumour growth for a subgroup of glioblastoma that affects teens and young adults – providing an important first step towards more effective treatment.
December 2020 –
Why Tumor Necrosis Might Not Be Good News for Some Patients With Glioblastoma
Researchers at Penn State College of Medicine have said that higher amounts of tissue death brought on by certain white blood cells have been associated with poor survival in patients with aggressive glioblastomas.
December 2020 –
Kazia Therapeutics’ (ASX:KZA) brain cancer drug selected for international study
“Kazia Therapeutics’ (KZA) paxalisib drug has been chosen for a multiple-therapy clinical trial in diffuse midline glioma.”
December 2020 –
New guidelines for treating the complications of brain tumours
An international team of researchers has now compiled international guidelines and standards for the treatment of common brain tumour complications.
November 2020 –
Is proton therapy the silver bullet for children with brain cancer?
A new study from the University of South Australia explores the efficacy of proton therapy in children with brain tumours.
November 2020 –
Novel nanoparticle therapy shows promise in glioblastoma
“The synthetic protein nanoparticle can cross the blood-brain barrier and deliver a targeted therapeutic to glioblastoma cells, say researchers.”
A new drug designed to work on cancers with an altered BRAF gene has shown promise in an early patient trial.
October 2020 – University of Calgary researchers discover new tactic to stop the growth of a deadly brain cancer: Findings indicate the body may be the ultimate weapon against glioblastoma, but it needs help
Big news out of the University of Calgary as researchers look at reprogramming the immune system to stop the growth of glioblastoma.
October 2020 –
Midatech Pharma is pleased to announce encouraging headline results from a Phase I study at the University of California, San Francisco in patients with Diffuse Intrinsic Pontine Glioma (“DIPG”).
October 2020 – Precision and Hope – Sunnybrook’s new MR-Linac machine
“Carefully lowering the MR-Linac through the roof of Sunnybrook’s Odette Cancer Centre, and into a specially constructed radiation treatment bunker, was a feat almost as massive as the six-tonne machine itself.”
Patients diagnosed early enough for certain lung tumours to be surgically removed, and who have a mutation of the so-called EGFR gene, found that Tagrisso cut the risk of developing brain metastases by 82%, a new study shows.
September 2020 – Brain tumour AI helping others
Artificial intelligence (AI) could play a role in diagnosing brain tumours, thanks to a branch of AI called Convolutional Neural Networks (CNN).
September 2020 –
Researchers find that CAR-T therapy can be effective reaching cells that spread from the primary tumour to other parts of the brain.
September 2020 –
A new technique of sensitizing stem cells to radiation therapy could have a significant effect on glioblastoma treatment.
September 2020 –
Gleolan is a substance that makes glioma tumour tissue glow fluorescent under special blue light, and has the potential to greatly increase successful surgical resections.
August 2020 –
Congratulations to former Brain Tumour Foundation of Canada award recipient Dr. Gelarah Zadeh on her new appointment as chair of neurosurgery at University of Toronto – the first woman to ever hold the post.
August 2020 –
“BioMark Diagnostics Inc. is pleased to announce that Health Canada has approved its clinical trial application (CTA) and has granted a Letter of No Objection (NOL) for its application entitled ACETYL-AMANTADINE AS A BIOMARKER IN PATIENTS WITH GLIOBLASTOMA.”
August 2020 –
A McGill-led study reveals that suppressing the OSMR gene can improve the effectiveness of radiation therapy in glioblastoma patients.
August 2020 – New drug targets for lethal brain cancer discovered
Researchers engineered a new mouse model for studying glioblastoma, the most aggressive type of brain cancer.
July 2020 –
An article exploring some of the newest oncologic drug targets, including those for glioblastoma, lung cancer and breast cancer.
July 2020 –
Researchers and clinicians from the University of Toronto and SickKids Hospital have found that a common diabetes drug may help repair brain injuries.
July 2020 –
“After discovering how a specific gene fuels a deadly form of children’s brain tumour, University of Manitoba researchers have successfully decreased this cancer in mice.”
Scientists have identified an oncogene (a cancer-causing gene) responsible for glioblastoma, offering a promising new treatment target for a cancer that is always fatal.
Empirica Therapeutics, a startup co-founded by Donnelly Centre investigator Jason Moffat and Dr. Sheila Singh, has been acquired by U.S.-based Century Therapeutics.
A new study out of Massachusetts shows that PAR glycohydrolase inhibitors can be used to enhance the effectiveness of chemotherapy in brain tumours.
For the first time, researchers detected what they describe as a progenitor glioblastoma stem cell (GSC) — a cell type from which all other cancer cells develop – part of five main cancer cell types within each tumour.
Halifax neurosurgeons are the first in Canada to use cutting-edge robotic technology to perform a brain biopsy.
Brain Tumour Foundation of Canada is among a panel of experts and medical professionals dedicated to developing Bruce Power’s isotope program.
June 2020 – Diagnosing brain tumors with a blood test
A simple blood test has been found that accurately diagnosed and classified various brain tumours, opening the door to more accurate diagnoses and less-invasive treatments.
In this consensus statement, an international group of experts present mitigation strategies and treatment guidance for patients suffering from high grade gliomas (HGGs) during the coronavirus disease 2019 (COVID-19) pandemic.
“For the past 70 years, the best indicator of life expectancy for a patient with glioblastoma (GBM) — the most common and the most aggressive brain cancer — has simply been age at diagnosis.”
A new treatment for lung cancer that shows promise in brain metastases.
High dose x-ray beams – narrower than a human hair – could be used to blast tumours while sparing the surrounding tissue in patients who have expended conventional radiation, thanks to researchers at the University of Saskatchewan.
Using new technology called ‘federated learning’, artificial intelligence will be able to gather data from participating researchers to help identify brain tumours without compromising the privacy of medical data.
A multi-institutional, international team led by researchers at The Hospital for Sick Children (SickKids) and Baylor College of Medicine, Texas Children’s Hospital has developed a novel approach that delivers appropriately-targeted chimeric antigen receptor (CAR) T cell therapy directly into the cerebrospinal fluid that surrounds the tumor.
A team of researchers have developed a novel methodology to predict, faster, whether or not a metastatic brain tumour would respond to radiotherapy.
A combination of radiation and the drug trifluoperazine not only targets glioblastoma cells but also helps overcome the resistance to treatment so common to this aggressive form of cancer. The results could prove promising for patients with the disease, for whom the median survival time is only 12 to 18 months following diagnosis.
A team of researchers for Yale School of Medicine and Beijing Normal University have published a breakthrough study on the use of nanoparticles as a way to deliver drug therapy through the blood-brain barrier.
Brain cancer in infants is biologically distinct from other childhood brain tumours and could be successfully treated with targeted drugs, a new study has shown.
April 2020 Understanding brain tumors in children
A European study into the molecular properties of medulloblastoma could lead to more effective treatments in children with certain genetic predispositions.
By analysing all protein-coding genes, researchers identify and replicate rare germline loss-of-function variants across ELP1 in 14% of paediatric patients with the medulloblastoma subgroup Sonic Hedgehog.
The University of Bristol (UK) is leading a project to develop an easy and affordable blood test kit that would have the ability to detect brain tumours. The project explores the use of fluorescent nanomaterials to assist in early diagnostics.
New research could revolutionize the way doctors tackle hard-to-treat conditions such as brain cancer, ALS and Alzheimer’s, thanks to a landmark $16.7 million grant that will go toward a new type of focused ultrasound device.
February 2020 Computer Simulation Helps Study Brain Cancer Growth
The growth of brain cancers can be better understood with the help of a new computer platform developed by international scientists coordinated by Newcastle University.
Scientists at The Institute of Cancer Research, London, the Mayo Clinic in Rochester, US, and the University of Leeds found that supercharging the mutation rate in cancer cells can create a powerful vaccine that is able to boost the effectiveness of immunotherapy.
February 2020 Bridging the gap between AI and the clinic
Researchers from The Neuro (Montreal Neurological Institute-Hospital) and the Montreal Children’s Hospital of the McGill University Health Centre have developed an open-source app that could bridge machine-learned algorithms with real world clinical practice.
February 2020 Childhood brain cancer: shedding light on tumor origin
A major discovery in the fight against childhood brain cancer has pointed to Peter Pan syndrome as a factor in the foetal development of deadly brain tumours. Peter Pan syndrome refers to the accidental stunting of cells that can then transform into malignant tumours.
February 2020 Robot Brings Companionship to Sick Kids
January 2020 Brain tumours manipulate neighbouring synapses
January 2020 Scientists Breach Brain Barrier To Tackle Tumours
December 2019 Electrospun Fibers Used for Brain Tumor Treatment
November 2019 The future of immunotherapy for glioblastoma
October 2019 Teaming up for brain tumour research
October 2019 Compound Kills Chemotherapy-resistant Cancer Cells
September 2019 U of A researchers move closer to ‘magic’ cancer treatment
September 2019 Mechanism behind glioblastoma survival revealed by study
September 2019 Existing Drug “Blocks” Brain Tumor Growth
August 2019 Simple blood test may help detect glioblastoma
August 2019 Immune-Activating Gene Therapy for Gliobastoma
August 2019 Six Western projects earn CFI backing
August 2019 New method to classify brain tumour in children
August 2019: Google maps for tumours and organs
August 2019: Novel nano-vaccine for melanoma developed
August 2019: Bringing Augmented Reality to Brain Surgery
July 2019: Cancer cells will become vulnerable
June 2019: Pituitary adenomas
May 2019: Hard knocks for brain cancer, again
April 2019: Magnetic nanoparticles can ‘burn’ cancer cells
March 2019: Study reveals the evolution of brain tumours
February 2019: Brain Cancer: Vibrating the brain to find resistant tumours
January 2019: Bruce Power to expand its role in health care
January 2019: U of L researchers studying cells in glioblastoma