Adam Bakos – Undergraduate Biochemistry and Biomedical Sciences Student, University of Windsor

Project: “Exploring cell cycle-targeting approaches against glioblastoma using 3d patient-derived systems and bioinformatics”

Generously funded by Taite Boomer Foundation

“Being awarded a Brain Tumour Research Studentship means opportunity. I am deeply honoured to be holding this award, and for this, I extend my deepest gratitude to the Taite Boomer Memorial Brain Tumour Foundation, enabling young researchers like me to strengthen the progression of research through the joint passion and generosity of this community.

As an individual who have personally experienced the hardships that come with a brain tumour diagnosis to a loved one, I strive to contribute to a future where the uncertainty behind this disease is eliminated. I recognize and hold closely that research is the root of discovery: the first step in developing solutions, improving outcomes, and enhancing the quality of life for patients and those close to them. Thus, the chance to not only work towards this future, but to connect with the donors and patients who share my sense of dedication in this field, and thus enhance my own personal growth, is an honour that I will never overlook.

Brain tumour research is my future, and I am extremely excited to be taking on this experience and investing into my career path with the support of my team and BTFC.”

Midpoint Report – October 2025

This summer, under the supervision of Dr. Lisa Porter and with support from Brain Tumour Foundation of Canada (BTFC), I studied the most prevalent adult brain tumour, glioblastoma. My research explores the molecular mechanisms governing the rapid proliferation and chemotherapy response of these aggressive, hard-to-treat cancers. Using fluorescent reporters, I specifically tracked the localization and behaviour of proteins that the Porter Lab has previously shown to be involved in glioblastoma. To facilitate high-throughput analysis, I collaborated with researchers from the Department of Computer Science to train an AI learning model capable of scoring reporter activity from single fluorescent images. We successfully developed a bioinformatics system to isolate cellular features and quantify fluorescence intensity within the nucleus and cytoplasm. This new system now provides the means to analyze samples throughout chemotherapy treatment. This also permits us to quantify patient samples grown as 3-dimensional organoids, an evolving technology which more closely resembles how the patient tumour responds to treatment and progresses in the body.

I am honoured to be part of this work and tremendously grateful to Brain Tumour Foundation of Canada and Taite Boomer Foundation. This studentship has reinforced my passion and commitment to the field of brain tumour research. Further, it has also supported the development of transferable skills, including critical thinking, project development, and written and verbal communication. I am eager to apply these newfound skills over the 2025/2026 school year as I progress on this project through my fourth-year undergraduate thesis. Hence, the knowledge and skills gained will also enhance my academic success, supporting my future career and aspirations. I look forward to what this project holds over the next year, including the summer 2026 studentship term. I am proud to express how this studentship acts as a reminder of why I am pursuing a career in this field. I am motivated more than ever to make an important contribution to brain tumour research and to all the patients and families affected by this devastating disease.