Alan Underhill – 2022 Research Grant Recipient

Generously funded by The Frazer Anderson Pediatric Research Grant, funded by Acuitas Therapeutics Inc.

Alan UnderhillAlan Underhill – University of Alberta, AB

Project Title: “Determinants of KMT5B dysfunction in pediatric glioma”

Description of Project:

Gliomas are a type of brain cancer and represent the most common solid tumor type seen in children. Although adults get these cancers with lower frequency, they are fundamentally different at the molecular level. Specifically, the types of DNA mutations that occur in these tumors in children are not the same as those in adults, suggesting the disease process is different and will likely require different approaches for treatment. In this proposal, we use multiple microscopy approaches to visualize cells from these childhood gliomas with the goal of understanding how their unique mutations cause this devastating disease. This knowledge can be applied to identifying strategies that enhance the utility of current treatments such as radiation therapy.

What receiving this award means:

“The funds received from the Brain Tumour Foundation of Canada will allow us to build on exciting preliminary results and are critical to sustaining longer term studies aimed at evaluating clinical utility in childhood brain cancers.”