Assistant Professor, Department of Pediatrics

University of Alberta

Project Title: “Functional modelling of FGFR alterations in pediatric low-grade gliomas to define therapeutic vulnerabilities”

Description of Project:

Pediatric low-grade gliomas are the most common brain tumours in children. While survival rates are generally high, tumours located in deep or critical areas of the brain can lead to significant long-term complications. These patients often require multiple treatments, which may cause side effects and are not always effective. Recent studies have identified alterations in FGFR genes in a subset of these tumours. These genetic changes may cause the tumour cells to grow uncontrollably and influence how the tumours respond to therapies, particularly new targeted drugs such as FGFR inhibitors. In this study, we will develop laboratory models (cell lines) with the different FGFR alterations to better understand how these different changes affect tumour growth and drug response. Our goal is to use this knowledge to guide the development of more effective and less toxic treatments for children with FGFR-altered low-grade gliomas.

What receiving this award means:

This award directly supports research focused on reducing treatment-related toxicity and improving long-term outcomes for children with pediatric low-grade gliomas.

On behalf of my research team and myself, I would like to sincerely thank the donors of BTFC for their generosity and belief in our work. I am truly honoured to receive this award, and it motivates me to continue working toward better treatments and improved quality of life for children and young adults living with pediatric low-grade gliomas.