Andrea Lo, Nazira Mamdani Brain Tumour Research Fellow

Project: Treatment approaches, outcomes and complications in adolescents and young adults of intracranial germ cell tumours

Location: BC Cancer Agency, Vancouver, BC and Princess Margaret Hospital, Toronto, ON.

Research Summary

Intracranial germ cell tumours (IGCT) affect both children and adults.  The treatment of IGCT in adolescents and young adults (AYA) is extrapolated from literature on children, due to the small proportion of AYA in most studies.  Treatment of IGCT involves radiotherapy (RT) alone or a combination of RT and chemotherapy.  RT is associated with significant late complications.  Chemotherapy alone, however is insufficient due to high rates of disease recurrence.  The reduction of the dose and volume of RT is being investigated in studies that are largely focused on children.  On the other hand, published and ongoing studies to guide management of IGCT in AYA are scarce, and therefore, treatment patterns in this group are variable.
The first part of this study is a national survey of physicians to assess treatment patterns of IGCT in AYA. Secondly, the medical records of AYA treated for IGCT in Toronto and British Columbia will be reviewed to determine outcomes and complications according to treatment approach.  Lastly, survivors will participate in a prospective evaluation of long-term complications and quality of life. The results will provide invaluable guidance in the management of ICGT in AYA, and aid in development of standard treatment guidelines for this population.

Andrea Lo describes what the research means to her:

"Being awarded the Nazira Mamdani Brain Tumour Research Fellowship means I have been generously granted the opportunity to grow and develop as a clinician investigator. I am passionate about research, and I look forward to making it a central part of my long-term career. This funding will support a study that will improve our understanding of intracranial germ cell tumours in adolescents and young adults, and will be an important step towards optimizing treatment and quality of life for patients affected by this disease. I am sincerely grateful to the family of Nazira Mamdani and the Brain Tumour Foundation of Canada for their contribution towards advancing medical knowledge and improving the lives of those affected by brain tumours."

From the first report:

The data collection and analysis of Part I (Canadian Patterns of Practice) and Part II (Outcomes and complications in the management of intracranial germ cell tumours) have been completed. Results have been submitted as abstracts to several conferences and presented as both poster and oral presentations (see report). Manuscripts for Part I and Part II will be written over the next 3 months. Part III of the study will be started next month and completed over the ensuing 14-15 months, including data collection, analysis and publication. Read the first year report (PDF).

This Brain Tumour Research Fellowship was established in 2014 in memory of Nazira Mamdani.

Nazira Mamdani was an avid community volunteer and activist. After graduating from the University of Alberta with a Bachelor of Science in Nursing and obtaining an additional certification in oncology nursing in 1991, she started her career at the Canadian Cancer Society and later established herself as an independent health consultant specializing in developing teaching resources and planning programs which have had a significant impact in the lives of many Albertans.
Some of Nazira’s accomplishments include the planning for "Best Beginnings" designed for pregnant teenagers, and the smoking regulations imposed on hospital campus for staff. In 1997, she led a team to organize a conference on women’s health in Calgary, which has now become the annual Women and Wellness Expo.
In November 2004 when her three children were all younger than 3 years old, Nazira was diagnosed with an oligioastrocytoma brain tumour. After a partial resection in 2005, Nazira fought back and became a volunteer with the Brain Tumour Foundation of Canada. 
The Nazira Mamdani Fellowship was established in her memory by her family and friends.
Help build Canada's brain tumour research community by funding a Brain Tumour Research Fellowship. Contact us at 1-800-265-5106, ext. 229 or at 

< Back to Research Fellowships

For more information about brain tumour research funding and programs, please contact:

Susan Ruypers
Research Program Specialist
1-800-265-5106 ext 240
Share This

Featured Story

Hats for Hope

Today, 8 Canadians will learn they have brain cancer. That's 3,000 Canadians each year. That's why we have launched Hats for Hope a nation-wide brain cancer awareness campaign and are calling on all Canadians to pledge support for brain cancer research. Join us in International Brain Tumour Awareness Week, October 20 - 27, 2018, or on October 24, 2018 – the first Brain Cancer Awareness Day in Canada – by wearing a hat, taking a selfie or group photo, and sharing it on social using #HatsForHope

Learn more


Childhood Brain Tumour Signs & Symptoms

Earlier this year, you gave us your feedback in a survey on brain tumour signs and symptoms. One of the things we did with that survey...

Learn more

Anthony's Story is Our Story

I would like to take the opportunity to share "our" story. It’s actually my best friend Anthony's story, but I use the term "our"...

Learn more

Upcoming Events

  • 24/Oct/2018: Ottawa Support Group: Meets at the Maplesoft Centre at 1500 Alta Vista Drive, Ottawa, ON.... Learn more >
  • 25/Oct/2018: Virtual Support Group East: Virtual Support Group for Eastern Canada... Learn more >
  • 27/Oct/2018: National Conference - Montreal: Hôtel Ruby Foo's, Montreal, QC & diffusion en direct... Learn more >
  • 27/Oct/2018: SUPERKIDS - A Quest to End Brain Tumours: CitiPlaza, London, ON... Learn more >
View All Events >
Thank you to the donors whose contributions make this website and all programs, services and research possible.

Copyright © 2018 Brain Tumour Foundation of Canada. Charitable Registration #BN118816339RR0001