Andrew Beharry – 2021 Research Grant Recipient

Generously Funded by the DUNN with Cancer Research Fund

Andrew BeharryAndrew Beharry – University of Toronto, Mississauga, ON

Project Title: “Predicting Temozolomide Resistance in Glioblastoma using an Activity­based Fluorescent chemosensor for MGMT”

Description of Project:

A clinicians’ goal is to accurately predict what drug{s) will be most effective on a patient in order to minimize time the patient may not have and eliminate exposure to toxic treatments without benefiting from a positive outcome. In glioblastoma (GBM), the most common brain cancer in adults, the first-line treatments are typically surgery and radiotherapy, followed by chemotherapy using the drug temozolomide (TMZ). Unfortunately, TMZ is ineffective on a large number of GBM patients as a consequence of the action of the DNA repair protein, 06- Methylguanine DNA Methyltransferase {MGMT). It is well established that patients having high levels of MGMT have a poorer response to TMZ therapy compared to those that have low levels. As such, MGMT has been well regarded as a predictive and prognostic marker of TMZ-based therapy. Our project describes the development and application of a small molecule fluorescent chemosensor that directly monitors the activity of MGMT. Our vision is to use our sensor on fresh biopsied tissue samples for GBM patients and predict patient response to TMZ-based therapy. As such, clinicians around the world can routinely and accurately assess the MGMT status in GBM patients to help govern their decision making in chemotherapeutic treatments.

What receiving this award means:

“It is a great honor to receive a research grant from Brain Tumour Foundation of Canada. This funding will allow our team to optimize and validate our fluorescent chemosensor technology so that we can ultimately help clinicians choose the most effective drugs for glioblastoma patients”.