Medical Student, University of Montreal

Generously funded in memory of Dale Lewington 

Supervisor: Dr. Sami Obaid

Project title: “Disconnectome Mapping Following Low-Grade Glioma Resection: Toward Improved Epilepsy Control” 

Description of the project: 

Seizures affect over 90% of patients with low-grade gliomas (LGGs). More than a localized mass, these tumours weave themselves into the brain’s healthy tissue, forming connections and creating chemical imbalances. This biological integration disrupts normal brain function, triggering disabling seizures. In turn, this neuronal hyperactivity promotes tumour growth, creating a vicious cycle between LGG and seizures. While surgery typically focuses on removing the visible tumour, modern science recognizes that seizures are a network-level problem. Through neuroplasticity—the brain’s ability to rewire itself—this “seizure network” can extend beyond the lesion; hence, surgery may not capture the entire epileptogenic area, leaving some patients without complete seizure control.

Our project targets epilepsy linked to LGGs. Using data from over 200 patients and advanced brain mapping, including tractography, we will identify key white matter connections whose transection is associated with the best seizure outcomes. Mapping this “disconnectome” will guide new surgical strategies to maximize seizure control. Successfully stopping seizures will not only improve quality of life and reduce reliance on antiseizure medications, which are often associated with cognitive, behavioural, and systemic side effects, but may also slow tumour progression by disrupting the feedback loop in which overactive neurons promote tumour growth.

Impact of receiving the award:

Being awarded a Brain Tumour Research Studentship means much more than having my project funded. It means my work is being recognized as truly impactful for patients, the ones for whom we endeavour and strive to find new and creative ways to tackle diseases. It means the long hours I spend trying to figure out how I may contribute to the well-being of those afflicted by brain tumours are not in vain. It means I can fulfil my greatest passion, unlocking the mysteries of the human brain, and add my work to the long list of incredible researchers.  

Ever since I learned about the importance and complexity of the human mind as a child, I have longed to become someone who could help decipher its many puzzles, if only a little more than my predecessors. More than an absolute fascination, I hope I may ease its many ailments. As a medical student, I wish to dedicate my life to helping the sick and their loved ones. I believe I am in an amazing position and that I have a duty to my future patients. This award is yet another reminder of who I am really doing this for.